Effects of stratospheric radiations on human glioblastoma cells (Articolo in rivista)

Type
Label
  • Effects of stratospheric radiations on human glioblastoma cells (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • M.P. CERU’, F. AMICARELLI, L. CRISTIANO, S. COLAFARINA, P. AIMOLA, S. FALONE, B. CINQUE, O. URSINI, R. MOSCARDELLI, P. RAGNI (2005)
    Effects of stratospheric radiations on human glioblastoma cells
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M.P. CERU’, F. AMICARELLI, L. CRISTIANO, S. COLAFARINA, P. AIMOLA, S. FALONE, B. CINQUE, O. URSINI, R. MOSCARDELLI, P. RAGNI (literal)
Pagina inizio
  • 276 (literal)
Pagina fine
  • 296 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 54 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Acknowledgment to: Prof. A. Aguilera, Dep. of Genetics, Univ. of Sevilla (Spain); Dr. C. Messina, Dep. of Sea Biology, Univ. of Trapani, Prof. A. Zanini INFN, Turin, ASI Milo Base. Work supported by the grant PRIA 2001 from the University of L’Aquila. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dept. of Basic and Applied Biology, Faculty of Sciences, University of L’Aquila, Via Vetoio, Coppito 67010 (AQ), Italy Dept. of Biomedical Sciences, Faculty of Medicine, University \"G. D’Annunzio\", Via dei Vestini, 66013 Chieti (CH), Italy Dept. of Experimental Medicine, Faculty of Medicine, University of L’Aquila, Via Vetoio, Coppito 67010 (AQ), Italy National Research Council (CNR), Chemical Methodologies Institute, Montelibretti, Roma, Italy (literal)
Titolo
  • Effects of stratospheric radiations on human glioblastoma cells (literal)
Abstract
  • The aim of this work was to evaluate the effect of stratospheric radiations on neural tumour cells. ADF human glioblastoma cells were hosted on a stratospheric balloon within the 2002 biological experiment campaign of the Italian Space Agency. The flight at an average height of 37 km lasted about 24 hrs. Cell morphology, number and viability, cell cycle and apoptosis, some antioxidant enzymes and proteins involved in cell cycle regulation, DNA repair and gene expression were studied. Stratospheric radiations caused a significant decrease in cell number, as well as a block of proliferation, but not apoptosis or necrosis. Radiations also induced activation and induction of some antioxidant enzymes, increase in DNA repair-related proteins (p53 and Proliferating Cell Nuclear Antigen) and variations of the transcription factors Peroxisome Proliferator-Activated Receptors. Morphologically, test cells exhibited more electron dense cytoplasm and less condensed chromatin than controls and modification of their surfaces. Our results indicate that glioblastoma cells, exposed to continuous stratospheric radiations for 24 hrs, show activation of cell cycle check point, decrease of cell number, variations of Peroxisome Proliferator-Activated Receptors and increase of Reactive Oxygen Species-scavenging enzymes. (literal)
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