http://www.cnr.it/ontology/cnr/individuo/prodotto/ID329233
Signaling by exosomal microRNAs in cancer (Articolo in rivista)
- Type
- Label
- Signaling by exosomal microRNAs in cancer (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1186/s13046-015-0148-3 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Germana Falcone, Armando Felsani and Igea D'Agnano (literal)
- Pagina inizio
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Cell Biology and Neurobiology, CNR, Via Ramarini 32-00015, Monterotondo, RM, Italy (literal)
- Titolo
- Signaling by exosomal microRNAs in cancer (literal)
- Abstract
- A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer
research since they play a central role in regulation of gene-expression and miRNA aberrant expression is found in
almost all types of human cancer. The discovery of circulating miRNAs in body fluids and the finding that they are
often tumor specific and can be detected early in tumorigenesis has soon led to the evaluation of their possible
use as cancer biomarkers and treatment-response predictors. The evidence that tumor cells communicate via the
secretion and delivery of miRNAs packed into tumor-released microvesicles has prompted to investigate miRNA
contribution as signaling molecules to the establishment and maintenance of the tumor microenvironment and the
metastatic niche in cancer. In this review we highlight the recent advances on the role of exosomal miRNAs as
mediators of cancer cell-to-cell communication. (literal)
- Autore CNR
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