6-Azido hyacinthacine A(2) gives a straightforward access to the first multivalent pyrrolizidine architectures (Articolo in rivista)

Type
Label
  • 6-Azido hyacinthacine A(2) gives a straightforward access to the first multivalent pyrrolizidine architectures (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c4ob01117a (literal)
Alternative label
  • D'Adamio, Giampiero; Parmeggiani, Camilla; Goti, Andrea; Moreno-Vargas, Antonio J.; Moreno-Clavijo, Elena; Robina, Inmaculada; Cardona, Francesca (2014)
    6-Azido hyacinthacine A(2) gives a straightforward access to the first multivalent pyrrolizidine architectures
    in Organic & biomolecular chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • D'Adamio, Giampiero; Parmeggiani, Camilla; Goti, Andrea; Moreno-Vargas, Antonio J.; Moreno-Clavijo, Elena; Robina, Inmaculada; Cardona, Francesca (literal)
Pagina inizio
  • 6250 (literal)
Pagina fine
  • 6266 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84904749329&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 17 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 32 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WoS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Chimica ugo Schiff, Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy; European Laboratory for Non Linear Spectroscopy (LENS), via Nello Carrara 1, 50019 Sesto Fiorentino (FI), Italy; CNR-INO, U.O.S. Sesto Fiorentino, via Nello Carrara 1, 50019 Sesto Fiorentino (FI), Italy; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, c/Prof. García González 1, E-41012 Sevilla, Spain (literal)
Titolo
  • 6-Azido hyacinthacine A(2) gives a straightforward access to the first multivalent pyrrolizidine architectures (literal)
Abstract
  • The synthesis of the first multivalent pyrrolizidine iminosugars is reported. The key azido intermediates 4 and 31 were prepared after suitable synthetic elaboration of the cycloadduct obtained from 1,3-dipolar cycloaddition of D-arabinose derived nitrone to dimethylacrylamide. The key step of the strategy was the stereoselective installation of an azido moiety at C-6 of the pyrrolizidine skeleton. The click reaction with different monovalent and dendrimeric alkyne scaffolds allowed the preparation of a library of new mono- and multivalent pyrrolizidine compounds that were preliminarily assayed as glycosidase inhibitors towards a panel of commercially available glycosyl hydrolases. (literal)
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