http://www.cnr.it/ontology/cnr/individuo/prodotto/ID328953
Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/MMP-1 Pathway. (Articolo in rivista)
- Type
- Label
- Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/MMP-1 Pathway. (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Alternative label
Carrizzo A1, Lenzi P2, Procaccini C3, Damato A1, Biagioni F1, Mariateresa A1, Amodio G4, Remondelli P5, Del Giudice C6, Izzo R6, Malovini A7, Formisano L8, Gigantino V9, Madonna M1, Puca AA10, Trimarco B6, Matarese G10, Fornai F11, Vecchione C12. (2015)
Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/MMP-1 Pathway.
in Circulation (N.Y.N.Y.)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Carrizzo A1, Lenzi P2, Procaccini C3, Damato A1, Biagioni F1, Mariateresa A1, Amodio G4, Remondelli P5, Del Giudice C6, Izzo R6, Malovini A7, Formisano L8, Gigantino V9, Madonna M1, Puca AA10, Trimarco B6, Matarese G10, Fornai F11, Vecchione C12. (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1IRCCS Neuromed, Pozzilli (IS), Italy.
2University of Pisa, Pisa, Italy.
3Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, (IEOS-CNR), Consiglio Nazionale delle Ricerche c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli \"Federico II\", Napoli, Italy.
4Università degli Studi di Salerno, Fisciano (Salerno), Italy & Università degli Studi di Salerno, Baronissi (Salerno), Italy.
5Università degli Studi di Salerno, Baronissi (Salerno), Italy.
6\"Federico II\" University of Naples, Italy.
7University of Pavia, Pavia, Italy.
8University of Sannio, Benevento, Italy.
9Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, (IEOS-CNR), Consiglio Nazionale delle Ricerche c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli \"Federico II\", Napoli, Italy & \"Istituto Nazionale Tumori, IRCCS, Fondazione Pascale\", Naples, Italy.
10Università degli Studi di Salerno, Baronissi (Salerno), Italy & IRCCS Multimedica, Milan, Italy.
11IRCCS Neuromed, Pozzilli (IS), Italy & University of Pisa, Pisa, Italy.
12IRCCS Neuromed, Pozzilli (IS), Italy & Università degli Studi di Salerno, Baronissi (Salerno), Italy cvecchione@unisa.it. (literal)
- Titolo
- Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/MMP-1 Pathway. (literal)
- Abstract
- BACKGROUND:
-Pentraxin 3 (PTX3), the prototype of long pentraxins, has been described associated with endothelial dysfunction in different cardiovascular disorders. So far, no study has evaluated the possible direct effect of PTX3 on vascular function.
METHODS AND RESULTS:
-Through in-vitro experiments of vascular reactivity and ultrastructural analyses, we demonstrate that PTX3 induces, per se, dysfunction and morphological changes of the endothelial layer through a P-selectin/metalloproteinase-1 (MMP1) pathway. The latter hampered the detachment of eNOS from Caveolin1, leading to an impairment of nitric oxide (NO) signaling. In vivo studies showed that the administration of PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice. In isolated endothelial cells (HUVEC), PTX3 significantly blunted NO production through the MMP1 pathway. Finally, using ELISA, we found that hypertensive patients (n=31) have higher plasma levels of PTX3 and its mediators P-Selectin and MMP1 than normotensive subjects (n=21).
CONCLUSIONS:
-Our data show for the first time a direct role of PTX3 on vascular function and blood pressure homeostasis, identifying the molecular mechanisms involved. The findings in humans suggest that PTX3, P-selectin and MMP-1 may be novel biomarkers that predict the onset of vascular dysfunction in hypertensive patients. (literal)
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