On the functional and structural characterization of hubs in protein-protein interaction networks (Articolo in rivista)

Type
Label
  • On the functional and structural characterization of hubs in protein-protein interaction networks (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.biotechadv.2012.12.002 (literal)
Alternative label
  • Bertolazzi P., Bock Mary E., Guerra C. (2013)
    On the functional and structural characterization of hubs in protein-protein interaction networks
    in Biotechnology advances; Elsevier, Oxford (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bertolazzi P., Bock Mary E., Guerra C. (literal)
Pagina inizio
  • 274 (literal)
Pagina fine
  • 286 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1016/j.biotechadv.2012.12.002 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Bertolazzi P., Istituto di Analisi dei Sistemi e Informatica \"A. Ruberti\"; Bock Mary E., Department of Statistics, Purdue University; Guerra C.. College of Computing Georgia Tech University. (literal)
Titolo
  • On the functional and structural characterization of hubs in protein-protein interaction networks (literal)
Abstract
  • A number of interesting issues have been addressed on biological networks about their global and local properties. The connection between the topological properties of proteins in Protein-Protein Interaction (PPI) networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large number of interacting partners. We will survey the literature trying to answer the following questions: Do hub proteins have special biological properties? Do they tend to be more essential than non-hub proteins? Are they more evolutionarily conserved? Do they play a central role in modular organization of the protein interaction network? Are there structural properties that characterize hub proteins? (literal)
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