Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (Articolo in rivista)

Type
Label
  • Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2203/dose-response.12-025 (literal)
Alternative label
  • I. Tedesco; C. Spagnuolo; M. Russo; R. Iannitti; A. Nappo; G.L. Russo. Protective effect of ?-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes. Dose-Response 11:401-12 (2013) (2013)
    Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes
    in Dose-response
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • I. Tedesco; C. Spagnuolo; M. Russo; R. Iannitti; A. Nappo; G.L. Russo. Protective effect of ?-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes. Dose-Response 11:401-12 (2013) (literal)
Pagina inizio
  • 401 (literal)
Pagina fine
  • 412 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.dose-response.com/ (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 11 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche (literal)
Titolo
  • Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (literal)
Abstract
  • Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in interventional cardiologists to counteract the oxidative damage caused by radiation. Here, we demonstrated in an in vitro model represented by whole blood of healthy donors ?-irradiated with 220-440 mGy, that haemolysis of erythrocytes induced by hypochlorous acid was reduced by 40%. The protection triggered by ?- radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous acid which was induced 3 h after irradiation and involved biochemical changes in the synthesis and turnover of glutathione. Overall, the biochemical remodelling induced by exposure to ?-radiations might contribute to generate new guidelines in professionally exposed workers. (literal)
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