http://www.cnr.it/ontology/cnr/individuo/prodotto/ID325381
Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (Articolo in rivista)
- Type
- Label
- Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2203/dose-response.12-025 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- I. Tedesco; C. Spagnuolo; M. Russo; R. Iannitti; A. Nappo; G.L. Russo. Protective effect of ?-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes. Dose-Response 11:401-12 (2013) (literal)
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- http://www.dose-response.com/ (literal)
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- Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche (literal)
- Titolo
- Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes (literal)
- Abstract
- Radiations may trigger protective response within a threshold of doses applied.
Exposures above an upper threshold are generally detrimental, while exposures below a
lower threshold may or may not increase risks for health. We recently reported that a cellular
protective response occurs in interventional cardiologists to counteract the oxidative
damage caused by radiation. Here, we demonstrated in an in vitro model represented by
whole blood of healthy donors ?-irradiated with 220-440 mGy, that haemolysis of erythrocytes
induced by hypochlorous acid was reduced by 40%. The protection triggered by ?-
radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous
acid which was induced 3 h after irradiation and involved biochemical changes in the synthesis
and turnover of glutathione. Overall, the biochemical remodelling induced by
exposure to ?-radiations might contribute to generate new guidelines in professionally
exposed workers. (literal)
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