Expression of HOX homeogenes in human neuroblastoma cell culture lines (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Expression of HOX homeogenes in human neuroblastoma cell culture lines (Articolo in rivista) (literal)

Anno

• 1990-01-01T00:00:00+01:00 (literal)

Alternative label

• Peverali, Fiorenzo A A; D'esposito, Maurizio; Acampora, Dario; Bunone, Giuseppe; Negri, Mario; Faiella, Antonio; Stornaiuolo, Anna; Pannese, Maria; Migliaccio, Enrica; Simeone, Antonio; Della Valle, Giuliano; Boncinelli, Edoardo (1990)
  Expression of HOX homeogenes in human neuroblastoma cell culture lines
  in Differentiation (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Peverali, Fiorenzo A A; D'esposito, Maurizio; Acampora, Dario; Bunone, Giuseppe; Negri, Mario; Faiella, Antonio; Stornaiuolo, Anna; Pannese, Maria; Migliaccio, Enrica; Simeone, Antonio; Della Valle, Giuliano; Boncinelli, Edoardo (literal)

Pagina inizio

• 61 (literal)

Pagina fine

• 69 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-0025013094&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 45 (literal)

Rivista

• Differentiation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics Adriano Buzzati Traverso (literal)

Titolo

• Expression of HOX homeogenes in human neuroblastoma cell culture lines (literal)

Abstract

• Mammalian genes containing a class-I homeo-box (HOX genes) are highly expressed in the embryonic nervous system. As a first step towards the molecular analysis of the role these genes play in neural cells, we studied the expression of four human HOX genes in five neuroblastoma (NB) cell lines - SK-N-BE, CHP-134, IMR-32, SK-N-SH and LAN-1 - during the process of differentiation induced by treatment with retinoic acid (RA). The four genes, HOX1D, 2F, 3E and 4B, located at corresponding positions in the four HOX loci, share a high degree of sequence similarity with the Drosophila Deformed homeotic gene and constitute a homology group, group 10. One of these genes, HOX1D, is not expressed in the cells used, whereas the other three are highly expressed in untreated RA-induced NB cells, even though the expression pattern in the various lines is slightly different for the three genes. Our analysis reveals a complex and specific expression pattern in these lines, paying the way to an identification of different NB-cell populations by means of specific HOX gene expression schemes. On the other hand, in every line studied, morphological maturation toward a neuronal differentiated phenotype appears to be associated with increased HOX gene expression. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• EDOARDO BONCINELLI (Unità di personale interno)
• DARIO ACAMPORA (Persona)
• ANTONIO FIORENZO PEVERALI (Persona)
• MAURIZIO D'ESPOSITO (Persona)
• ANTONIO SIMEONE (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR di

• MAURIZIO D'ESPOSITO (Persona)
• ANTONIO FIORENZO PEVERALI (Persona)
• ANTONIO SIMEONE (Persona)
• DARIO ACAMPORA (Persona)
• EDOARDO BONCINELLI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Differentiation (Rivista)