Association of central serotonin transporter availability and body mass index in healthy Europeans (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Association of central serotonin transporter availability and body mass index in healthy Europeans (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.euroneuro.2014.05.005 (literal)

Alternative label

• Hesse, Swen; Van De Giessen, Elsmarieke M.; Zientek, Franziska; Petroff, David; Winter, Karsten; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Darcourt, Jacques; Akdemir, Ümit Özgür; Knudsen, Gitte Moos; Nobili, Flavio Mariano; Pagani, Marco; Vander Borght, Thierry M.; Van Laere, Koen Van R; Varrone, Andrea; Tatsch, Klaus; Sabri, Osama; Booij, Jan (2014)
  Association of central serotonin transporter availability and body mass index in healthy Europeans
  in European neuropsychopharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Hesse, Swen; Van De Giessen, Elsmarieke M.; Zientek, Franziska; Petroff, David; Winter, Karsten; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Darcourt, Jacques; Akdemir, Ümit Özgür; Knudsen, Gitte Moos; Nobili, Flavio Mariano; Pagani, Marco; Vander Borght, Thierry M.; Van Laere, Koen Van R; Varrone, Andrea; Tatsch, Klaus; Sabri, Osama; Booij, Jan (literal)

Pagina inizio

• 1240 (literal)

Pagina fine

• 1247 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84905041212&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• European neuropsychopharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Universitat Leipzig; Universitatsklinikum Leipzig und Medizinische Fakultat; Academic Medical Centre, University of Amsterdam; Centre for Clinical Studies; Translational Centre for Regenerative Medicine (TRM) Leipzig; UCL; Southampton University Hospitals NHS Trust; Szegedi Tudomanyegyetem; Medizinische Universitat Wien; Universite Nice Sophia Antipolis; Gazi Universitesi; Rigshospitalet; Universita degli Studi di Genova; Karolinska University Hospital; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universite Catholique de Louvain; University Hospital Leuven; Karolinska Institutet; Ludwig-Maximilians-Universitat Munchen; Municipal Hospital Karlsruhe Inc. (literal)

Titolo

• Association of central serotonin transporter availability and body mass index in healthy Europeans (literal)

Abstract

• Serotonin-mediated mechanisms,inparticularviatheserotonintransporter(SERT),arethought to haveaneffectonfoodintakeandplayanimportantroleinthepathophysiologyofobesity. However,imagingstudiesthatexaminedthecorrelationbetweenbodymassindex(BMI)and SERTaresparseandprovidedcontradictoryresults.Theaimofthisstudywastofurthertestthe association betweenSERTandBMIinalargecohortofhealthysubjects. Methods: 127subjects of theENCDATdatabase(58females,age52718 years,range20-83, BMI25.273.8 kg/m2, range 18.2-41.1) wereanalysedusingregion-of-interest(ROI)andvoxel-basedapproachesto calculate [123I]FP-CIT specific-to-nonspecific bindingratios(SBR)inthehypothalamus/thalamus and midbrain/brainstemasSERT-specific targetregions. Results: Inthevoxel-basedanalysis, SERTavailabilityandBMIwerepositivelyassociatedinthethalamus,butnotinthemidbrain. In theROI-analysis,theinteractionbetweengenderandBMIshowedatrendwithhigher correlation coefficient formeninthemidbrainalbeitnotsignificant (0.033SBRm2/kg, p=0.1). Conclusions: ThedataareinagreementwithpreviousPET findings ofanalteredcentral serotonergic tonedependingonBMI,asaprobablepathophysiologicmechanisminobesity,and should encouragefurtherclinicalstudiesinobesitytargetingtheserotonergicsystem. (literal)

Prodotto di

• Neuropatologie e bisogni individuali: diagnostica per immagini, assessment linguistico-cognitivo, counseling genetico e trattamento riabilitativo (ME.P02.015.001) (Modulo)
• Institute of cognitive sciences and technologies (ISTC) (Istituto)

Autore CNR

• MARCO PAGANI (Persona)

Insieme di parole chiave

• Keywords of "Association of central serotonin transporter availability and body mass index in healthy Europeans" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARCO PAGANI (Persona)

Prodotto

• Institute of cognitive sciences and technologies (ISTC) (Istituto)
• Neuropatologie e bisogni individuali: diagnostica per immagini, assessment linguistico-cognitivo, counseling genetico e trattamento riabilitativo (ME.P02.015.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European neuropsychopharmacology (Rivista)

Insieme di parole chiave di

• Keywords of "Association of central serotonin transporter availability and body mass index in healthy Europeans" (Insieme di parole chiave)