Towards an integrative model of the PI3K/Akt metabolic effects (Contributo in atti di convegno)

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Label
  • Towards an integrative model of the PI3K/Akt metabolic effects (Contributo in atti di convegno) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mosca E.(1), Barcella M.(1), Alfieri R.(1), Bevilacqua A.(2,3), Milanesi L.(1) (2011)
    Towards an integrative model of the PI3K/Akt metabolic effects
    in International Meeting on Computational Intelligence (CIBB), Gargano del Garda, 30 giugno-2 luglio 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mosca E.(1), Barcella M.(1), Alfieri R.(1), Bevilacqua A.(2,3), Milanesi L.(1) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) Institute for Biomedical Technologies, CNR, 20090 Segrate (MI), Italy (2) Universita ? Telematica San Raffaele Roma, 00166 Rome, Italy (3) Department of Pharmacology, Universita ? degli Studi di Milano, 20129 Milan, Italy (literal)
Titolo
  • Towards an integrative model of the PI3K/Akt metabolic effects (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-3-642-35685-8 (literal)
Abstract
  • Cancer cells differ from their normal counterparts more in terms of regulatory networks than of specific molecules. A recently recognized hallmark of cancer is the increased uptake of nutrients, particularly glucose, associated with a higher lactate pro- duction. A common step of tumorigenesis, which influences these metabolic alterations, is the constitutive activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Fol- lowing an integrative systems biology approach, we propose a model for the in silico investigation of the PI3K/Akt pathway effects on the central metabolism. This model represents a useful tool for the computational analysis of the metabolic differences be- tween normal and pathological conditions. (literal)
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