Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (Brevetto)

Type
Label
  • Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (Brevetto) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • LA MOTTA C, DA SETTIMO F, DARIO B, SARTINI S, BASTA G, DEL TURCO S, SAPONARO C (2013)
    Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus
    (literal)
Titolo
  • Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • LA MOTTA C, DA SETTIMO F, DARIO B, SARTINI S, BASTA G, DEL TURCO S, SAPONARO C (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • International Patent Classification: A61K-031/519; A61P-007/00; C07D-471/04; C07D-000/00 Derwent Class Code(s): B02 (Fused ring heterocyclics) Derwent Manual Code(s): B06-D06; B14-F01G; B14-F04; B14-L06 Patent Details: Patent Number Publ. Date Main IPC Week Page Count Language WO2013144860-A1 03 Oct 2013 C07D-471/04 201368 Pages: 20 English IT1410639-B 17 Sep 2014 C07D-000/00 201470 Italian (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#proprieta
  • 33% (literal)
Http://www.cnr.it/ontology/cnr/brevetti.owl#tipoDiBrevetto
  • Internazionale (literal)
Numero brevetto
  • WO2013144860-A1 (literal)
Anno di deposito
  • 2013 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IFC-CNR CONSIGLIO NAZ RICERCHE SCUOLA SUPERIORE SANT'ANNA UNIV PISA (literal)
Titolo
  • Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (literal)
Http://www.cnr.it/ontology/cnr/brevetti.owl#annoDiConcessione
  • 2013 (literal)
Abstract
  • NOVELTY - Agent comprises compounds with a 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus. USE - The agent is useful: for the treatment of blood vessels accessed via a percutaneous procedure; for treatment combined with the use of coronary stents (all claimed); and for treating restenosis and thrombosis with anti-atherogenic and anti-inflammatory properties. Test details are described but no results given. ADVANTAGE - The agent: reduces the risk of death due to a coronary event; and reduces the cost associated with repeated revascularization. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) a medication comprising the therapeutic agent; and (2) a procedure for implementing the agent comprising: condensating 2-aminopyridine with substituted beta -keto ester compound of formula (I) in the presence of phenylpropanolamine to obtain substituted 2-phenyl-pyrido(1,2-a)pyrimidine-4-one heterocyclic compound of formula (II); brominating (II) in the presence of N-bromosuccinimide and chloroform to obtain substituted brominated heterocyclic compound of formula (III); replacing the bromine atom with phenylic group by suspending (III) in toluene to which bis(triphenylphosphine)palladium chloride is added to substituted phenylboronic acid compound of formula (IIIa) to obtain substituted 2,3-diphenylpyrido(1 ,2-a)pyrimidine-4-one compound of formula (IV); and hydrolyzing the methoxy derivates of (IV), and reacting (IV) in the presence of borontribromide to obtain substituted 2,3-diphenylpyrido(1 ,2-a)pyrimidine-4-one compound of formula (V). (literal)
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