http://www.cnr.it/ontology/cnr/individuo/prodotto/ID323010
Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (Brevetto)
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- Label
- Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (Brevetto) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
LA MOTTA C, DA SETTIMO F, DARIO B, SARTINI S, BASTA G, DEL TURCO S, SAPONARO C (2013)
Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus
(literal)
- Titolo
- Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- LA MOTTA C, DA SETTIMO F, DARIO B, SARTINI S, BASTA G, DEL TURCO S, SAPONARO C (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- International Patent Classification: A61K-031/519; A61P-007/00; C07D-471/04; C07D-000/00
Derwent Class Code(s): B02 (Fused ring heterocyclics)
Derwent Manual Code(s): B06-D06; B14-F01G; B14-F04; B14-L06
Patent Details:
Patent Number Publ. Date Main IPC Week Page Count Language
WO2013144860-A1 03 Oct 2013 C07D-471/04 201368 Pages: 20 English
IT1410639-B 17 Sep 2014 C07D-000/00 201470 Italian (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#proprieta
- Http://www.cnr.it/ontology/cnr/brevetti.owl#tipoDiBrevetto
- Numero brevetto
- WO2013144860-A1 (literal)
- Anno di deposito
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IFC-CNR CONSIGLIO NAZ RICERCHE
SCUOLA SUPERIORE SANT'ANNA
UNIV PISA (literal)
- Titolo
- Agent, useful e.g. for the treatment of blood vessels accessed via a percutaneous procedure and for treatment combined with the use of coronary stents, comprises compounds with 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus (literal)
- Http://www.cnr.it/ontology/cnr/brevetti.owl#annoDiConcessione
- Abstract
- NOVELTY - Agent comprises compounds with a 2,3-diphenyl-4H-pyrido(1,2-a)pyrimidine-4-one nucleus.
USE - The agent is useful: for the treatment of blood vessels accessed via a percutaneous procedure; for treatment combined with the use of coronary stents (all claimed); and for treating restenosis and thrombosis with anti-atherogenic and anti-inflammatory properties. Test details are described but no results given.
ADVANTAGE - The agent: reduces the risk of death due to a coronary event; and reduces the cost associated with repeated revascularization.
DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for:
(1) a medication comprising the therapeutic agent; and
(2) a procedure for implementing the agent comprising: condensating 2-aminopyridine with substituted beta -keto ester compound of formula (I) in the presence of phenylpropanolamine to obtain substituted 2-phenyl-pyrido(1,2-a)pyrimidine-4-one heterocyclic compound of formula (II); brominating (II) in the presence of N-bromosuccinimide and chloroform to obtain substituted brominated heterocyclic compound of formula (III); replacing the bromine atom with phenylic group by suspending (III) in toluene to which bis(triphenylphosphine)palladium chloride is added to substituted phenylboronic acid compound of formula (IIIa) to obtain substituted 2,3-diphenylpyrido(1 ,2-a)pyrimidine-4-one compound of formula (IV); and hydrolyzing the methoxy derivates of (IV), and reacting (IV) in the presence of borontribromide to obtain substituted 2,3-diphenylpyrido(1 ,2-a)pyrimidine-4-one compound of formula (V). (literal)
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