Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study (Articolo in rivista)
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- Prodotto della ricerca (Classe)
- Articolo in rivista (Classe)
- Label
- Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00411-014-0580-3 (literal)
- Alternative label
- Krille L, Dreger S, Schindel R, Albrecht T, Asmussen M, Barkhausen J, Berthold JD, Chavan A, Claussen C, Forsting M, Gianicolo EA, Jablonka K, Jahnen A, Langer M, Laniado M, Lotz J, Mentzel HJ, Queißer-Wahrendorf A, Rompel O, Schlick I, Schneider K, Schumacher M, Seidenbusch M, Spix C, Spors B, Staatz G, Vogl T, Wagner J, Weisser G, Zeeb H, Blettner M. (2015)(literal)
Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study
in Radiation and environmental biophysics; Springer, London (Regno Unito)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Krille L, Dreger S, Schindel R, Albrecht T, Asmussen M, Barkhausen J, Berthold JD, Chavan A, Claussen C, Forsting M, Gianicolo EA, Jablonka K, Jahnen A, Langer M, Laniado M, Lotz J, Mentzel HJ, Queißer-Wahrendorf A, Rompel O, Schlick I, Schneider K, Schumacher M, Seidenbusch M, Spix C, Spors B, Staatz G, Vogl T, Wagner J, Weisser G, Zeeb H, Blettner M. (literal)
- Pagina inizio
- 1 (literal)
- Pagina fine
- 12 (literal)
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- 51 (literal)
- Rivista
- Radiation and environmental biophysics (Rivista)
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- 12 (literal)
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- 1 (literal)
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- 1. L Krille, University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, 55131 Mainz 2. S Mueller, Leibniz - Institute for Prevention Research and Epidemiology - BIPS, 28359 Bremen 3. R Schindel, University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, 55131 Mainz 4. T Albrecht, Vivantes, Klinikum Neukölln, Institut für Radiologie und Interventionelle Therapie, 12351 Berlin 5. M Asmussen, Städtisches Klinikum Karlsruhe, Zentralinstitut für Bildgebende Diagnostik, 76133 Karlsruhe 6. J Barkhausen, Universitätsklinikum Schleswig Holstein, Campus Lübeck, Klinik für Radiologie und Nuklearmedizin, 23538 Lübeck 7. JD Berthold, Medizinische Hochschule Hannover, Institut für Diagnostische und Interventionelle Radiologie, 30625 Hannover 8. A Chavan, Klinikum Oldenburg gGmbH, Institut für Diagnostische & Interventionelle Radiologie, 26133 Oldenburg 9. B Claussen, Universitätsklinikum Tübingen, Abt. für Diagnostische und Interventionelle Radiologie, 72076 Tübingen 10. M Forsting, Universitätsklinikum Essen, Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, 45147 Essen 11. EAL Gianicolo, National Research Council, Institute of Clinical Physiology, 73100 Lecce & University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, 55131 Mainz 12. K Jablonka, Klinikum Bremen-Mitte, Klinik für Radiologische Diagnostik und Nuklearmedizin, 28177 Bremen 13. A Jahnen, Centre de Recherche Public Henri Tudor, 1855 Luxembourg 14. M Langer, Universitätsklinikum Freiburg, Klinik für Radiologie, 79106 Freiburg 15. M Laniado, Universitätsklinikum Carl Gustav Carus Dresden, Institut und Poliklinik für Radiologische Diagnostik, 01307 Dresden 16. J Lotz, Universitätsmedizin Göttingen, Institut für Diagnostische und Interventionelle Radiologie, 37075 Göttingen 17. HJ Mentzel, Universitätsklinikum Jena, Institut für Diagnostische und Interventionelle Radiologie, Sektion Kinderradiologie, 07740 Jena 18. A Queißer-Wahrendorf, Universitätsmedizin Mainz, Zentrum für Kinder- und Jugendmedizin, 55131 Mainz 19. O Rompel, Universitätsklinikum Erlangen, Radiologisches Institut, 91054 Erlangen 20. J Schlick, Klinikum Nürnberg Süd, Institut für Radiologie und Neuroradiologie, 90471 Nürnberg 21. K Schneider, Klinikum der Universität München, Dr. von Haunersches Kinderspital, Institut für Klinische Radiologie, 80337 München 22. M Schumacher, Universitätsklinik Freiburg, Klinik für Neuroradiologie, Neurozentrum, 78106 Freiburg 23. M Seidenbusch, Klinikum der Universität München, Dr. von Haunersches Kinderspital, Institut für Klinische Radiologie und Kinderradiologie, 80337 München 24. C Spix, German Childhood Cancer Registry at the University Medical Center Mainz, 55131 Mainz, 55131 Mainz 25. B Spors, Charité - Universitätsmedizin Berlin, Kinderradiologie, Standort Campus Virchow Klinikum, 13353 Berlin 26. G Staatz, Universitätsmedizin Mainz, Klinik und Poliklinik für diagnostische und interventionelle Radiologie, Sektion Kinderradiologie, 55131 Mainz 27. T Vogl, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt/Main, Institut für Diagnostische und Interventionelle Radiologie, 60590 Frankfurt 28. J Wagner, Vivantes, Klinikum im Friedrichshain, Institut für Radiologie und Interventionelle Therapie, 10249 Berlin 29. G Weisser, Universitätsklinikum Mannheim, Institut für Klinische Radiologie und Nuklearmedizin, 68167 Mannheim 30. H Zeeb, Leibniz - Institute for Prevention Research and Epidemiology - BIPS, Research Focus Health Sciences Bremen, University of Bremen, 28359 Bremen 31. Maria Blettner, University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, 55131 Mainz (literal)
- Titolo
- Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study (literal)
- Abstract
- The aim of this cohort study was to assess the risk of developing cancer, specifically leukaemia, tumours of the central nervous system and lymphoma, before the age of 15 years in children previously exposed to computed tomography (CT) in Germany. Data for children with at least one CT between 1980 and 2010 were abstracted from 20 hospitals. Cancer cases occurring between 1980 and 2010 were identified by stochastic linkage with the German Childhood Cancer Registry (GCCR). For all cases and a sample of non-cases, radiology reports were reviewed to assess the underlying medical conditions at time of the CT. Cases were only included if diagnosis occurred at least 2 years after the first CT and no signs of cancer were recorded in the radiology reports. Standardised incidence ratios (SIR) using incidence rates from the general population were estimated. The cohort included information on 71,073 CT examinations in 44,584 children contributing 161,407 person-years at risk with 46 cases initially identified through linkage with the GCCR. Seven cases had to be excluded due to signs possibly suggestive of cancer at the time of first CT. Overall, more cancer cases were observed (O) than expected (E), but this was mainly driven by unexpected and possibly biased results for lymphomas. For leukaemia, the SIR (SIR = O/E) was 1.72 (95 % CI 0.89-3.01, O = 12), and for CNS tumours, the SIR was 1.35 (95 % CI 0.54-2.78, O = 7). Despite careful examination of the medical information, confounding by indication or reverse causation cannot be ruled out completely and may explain parts of the excess. Furthermore, the CT exposure may have been underestimated as only data from the participating clinics were available. This should be taken into account when interpreting risk estimates. (literal)
- Editore
- Springer (Editore)
- Prodotto di
- Istituto di fisiologia clinica (IFC) (Istituto)
- Autore CNR
- EMILIO ANTONIO LUCA GIANICOLO (Unità di personale interno)
- Insieme di parole chiave
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- Istituto di fisiologia clinica (IFC) (Istituto)
- Autore CNR di
- EMILIO ANTONIO LUCA GIANICOLO (Unità di personale interno)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Radiation and environmental biophysics (Rivista)
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- Springer (Editore)
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