VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria (Articolo in rivista)

Type
Label
  • VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/cdd.2011.92 (literal)
Alternative label
  • De Stefani, D.; Bononi, A.; Romagnoli, A.; Messina, A.; De Pinto, V.; Pinton, P.; Rizzuto, R. (2012)
    VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
    in Cell death and differentiation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Stefani, D.; Bononi, A.; Romagnoli, A.; Messina, A.; De Pinto, V.; Pinton, P.; Rizzuto, R. (literal)
Pagina inizio
  • 267 (literal)
Pagina fine
  • 273 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/21720385 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1, 3, 7: Department of Biomedical Sciences, University of Padova and CNR Neuroscience Institute, Padua, Italy; 2, 6: Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation and BioPharmaNet, University of Ferrara, Ferrara, Italy; 4, 5: Department of Biology, Section of Molecular Biology, University of Catania and National Institute of Biostructures and Biosystems, Catania, Italy (literal)
Titolo
  • VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria (literal)
Abstract
  • Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect. Although all three VDAC isoforms are equivalent in allowing mitochondrial Ca2+ loading upon agonist stimulation, VDAC1 silencing selectively impairs the transfer of the low-amplitude apoptotic Ca2+ signals. Co-immunoprecipitation experiments show that VDAC1, but not VDAC2 and VDAC3, forms complexes with IP3 receptors, an interaction that is further strengthened by apoptotic stimuli. These data highlight a non-redundant molecular route for transferring Ca2+ signals to mitochondria in apoptosis. Cell Death and Differentiation (2012) 19, 267-273; doi:10.1038/cdd.2011.92; published online 1 July 2011 (literal)
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