The ZFP57 imprinting factor and epigenetic control: further clues stemming from expression profiling, ChIP seq and in vitro-induced differentiation (Abstract/Poster in atti di convegno)

Type
Label
  • The ZFP57 imprinting factor and epigenetic control: further clues stemming from expression profiling, ChIP seq and in vitro-induced differentiation (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Genesia Manganelli1, Italia De Feis2, Claudia Angelini2, Vincenzo Riso1, Ugo Masullo1, Amelia Cimmino1, Stefania Filosa1, Andrea Riccio1, Antonio Simeone1, Giovanna Grimaldi1 (2012)
    The ZFP57 imprinting factor and epigenetic control: further clues stemming from expression profiling, ChIP seq and in vitro-induced differentiation
    in 12th FISV Congress, Rome-Italy, 24-27/09/2012
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Genesia Manganelli1, Italia De Feis2, Claudia Angelini2, Vincenzo Riso1, Ugo Masullo1, Amelia Cimmino1, Stefania Filosa1, Andrea Riccio1, Antonio Simeone1, Giovanna Grimaldi1 (literal)
Pagina inizio
  • 78 (literal)
Pagina fine
  • 78 (literal)
Note
  • Abstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Istituto di Genetica e Biofisica Adriano Buzzati-Traverso, Consiglio Nazionale delle Ricerche, Naples, Italy 2Istituto per le Applicazioni del Calcolo \"Mauro Picone\", Consiglio Nazionale delle Ricerche, Naples, Italy (literal)
Titolo
  • The ZFP57 imprinting factor and epigenetic control: further clues stemming from expression profiling, ChIP seq and in vitro-induced differentiation (literal)
Abstract
  • Epigenetic marks are key to embryogenesis and are linked to the regulation of pluripotency, cell fate and cellular identity. Extensive epigenetic reprogramming occurs at early embryos stages and exceptions are the parent of origin-specific signatures at Imprinting Control Regions (ICRs) driving regulation of imprinted genes. ZFP57 was shown to be required for the maintenance of DNA methylation at ICRs in embryos and of both DNA methylation and histone H3 modification in embrional stem cells (ES). ZFP57 associates with KAP1, a recruiter of chromatin modifiers including the H3 methyltransferase SETDB1 and HP1, thus promoting H3 K9-trimethylation and chromoproteins assembly at targeted sites. ChIP seq profiling in ES cells of endogenous ZFP7 and associated factors shows assembly at hundreds regions in addition to imprinted loci and we will report on ongoing studies that integrate expression profiling, genome-wide occupancy, the status of selected targets and in vitro cell differentiation that suggest a wider role for ZFP57 in shaping the pluripotent epigenome and provide further clues for its involvement in development and cell fate. (literal)
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