Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/sj.bjc.6690734 (literal)

Alternative label

• Mezzelani, A; Tornielli, S; Minoletti, F; Pierotti, MA; Sozzi, G; Pilotti, S (1999)
  Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group
  in British Journal of Cancer
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mezzelani, A; Tornielli, S; Minoletti, F; Pierotti, MA; Sozzi, G; Pilotti, S (literal)

Pagina inizio

• 586 (literal)

Pagina fine

• 591 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 81 (literal)

Rivista

• British Journal of Cancer (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Fondazione IRCCS Istituto Nazionale Tumori Milan; Fondazione IRCCS Istituto Nazionale Tumori Milan (literal)

Titolo

• Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group (literal)

Abstract

• Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing's tumour (pPNETs-ETs). Its anatomical location, in addition to morphologic, immunophenotypic and ultrastructural features, suggests its origin in the neuronal or neuroendocrine cells of the olfactory epithelium. However, the cytogenetic and molecular data currently available appear controversial on the presence of the typical translocation t(11;22)(q24;q12) and of trisomy 8, chromosomal changes that characterize the tumours belonging to the pPNETs-ETs. Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence in situ hybridization (FISH), for the presence of EWS gene rearrangements by FISH, reverse transcription polymerase chain reaction and Southern blot analyses, as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by immunohistochemistry. Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case only. Moreover, DNA from three cases analysed by Southern blot did not show EWS gene rearrangements. Our results support the evidence that ENB is not a member of the pPNETs-ETs. (C) 1999 Cancer Research Campaign. (literal)

Autore CNR

• ALESSANDRA MARIA MEZZELANI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ALESSANDRA MARIA MEZZELANI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• British Journal of Cancer (Rivista)

Insieme di parole chiave di

• Parole chiave di "Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour Ewing's group" (Insieme di parole chiave)