\"Anxiety\" state in Sardinian alcohol-preferring rats exposed to an unpredictable schedule of limited access to multiple alcohol concentrations (Abstract/Poster in atti di convegno)

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Label
  • \"Anxiety\" state in Sardinian alcohol-preferring rats exposed to an unpredictable schedule of limited access to multiple alcohol concentrations (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Colombo G, Maccioni P, Lobina C, Zaru A, Carai MAM, Porcu P and Gessa GL (2014)
    "Anxiety" state in Sardinian alcohol-preferring rats exposed to an unpredictable schedule of limited access to multiple alcohol concentrations
    in 37th Annual Scientific Meeting of the Research Society on Alcoholism, Bellevue, WA, USA, 21-25 June 2014
    (literal)
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  • Colombo G, Maccioni P, Lobina C, Zaru A, Carai MAM, Porcu P and Gessa GL (literal)
Pagina inizio
  • 10A (literal)
Pagina fine
  • 10A (literal)
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  • Special Issue: Abstracts from the 37th Annual Scientific Meeting of the Research Society on Alcoholism (literal)
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  • 38 (literal)
Rivista
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  • 1 (literal)
Note
  • Poster (literal)
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  • Neuroscience Institute, National Research Council of Italy, Section of Cagliari, I-09042 Monserrato, CA, Italy (literal)
Titolo
  • \"Anxiety\" state in Sardinian alcohol-preferring rats exposed to an unpredictable schedule of limited access to multiple alcohol concentrations (literal)
Abstract
  • Recent research from this lab has found that exposure of selectively bred, Sardinian alcohol-preferring (sP) rats to multiple alcohol concentrations (10%, 20%, and 30%, v/v), under the 4-bottle \"alcohol vs water\" choice regimen, in daily drinking sessions of one hour and with unpredictable time schedule, promoted exceptionally high intakes of alcohol. Specifically, alcohol intake rose progressively as the drinking session moved from the earliest hours to the latest hours of the dark phase of the light/dark cycle; when the drinking session occurred during the 1st and 12th hour of the dark phase, alcohol intake averaged 0.7-0.8 and >=2 g/kg, respectively. The present study was aimed at investigating whether these largely different intakes were associated to alterations in the rats' emotional state. To this end, sP rats were initially exposed to 12 drinking sessions of one hour and during one of the 12 hours of the dark phase; time of alcohol exposure was changed daily under a semi-random order and was unpredictable to rats; on the 13th day, rats were divided into two groups and exposed to the Social Interaction (SI) test at the 1st and 12th hour of the dark phase, respectively. Alcohol was not available on the test day. Pairs (n=8) of rats exposed to the SI test during the 12th hour spent approximately 35% less time in \"social\" behaviors (e.g.: sniffing, following, walking over, crawling over and under, grooming the partner) than pairs (n=9) of rats exposed to the SI test during the 1st hour. These results indicate that expectation of alcohol generated an \"anxiety\" state in sP rats. A progressively increasing emotional \"distress\" might therefore be the neurobiological basis of the exceptionally high intakes of alcohol recorded in sP rats when exposed to this unique alcohol drinking protocol. Supported by NIAAA-funded \"Integrative Neuroscience Initiative on Alcoholism\" (INIAStress) Consortium. (literal)
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