Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab (Articolo in rivista)

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Label
  • Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2217/pgs.14.140 (literal)
Alternative label
  • Allegrini, Giacomo; Coltelli, Luigi; Orlandi, Paola G.; Fontana, Andrea O.; Camerini, Andrea; Ferro, Antonella; Cazzaniga, Marina; Casadei, Virginia; Lucchesi, Sara; Bona, Eleonora; Di Lieto, Marco; Pazzagli, Ilaria; Villa, Federica; Amoroso, Domenico; Scalese, Marco U.; Arrighi, Giada; Molinaro, Sabrina; Fioravanti, Anna; Finale, Chiara; Triolo, Renza; Di Desidero, Teresa; Donati, Sara; Marcucci, Lorenzo; Goletti, Orlando; Del Re, Marzia; Salvadori, Barbara; Ferrarini, Ilaria; Danesi, Romano; Falcone, Alfredo; Bocci, Guido (2014)
    Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab
    in Pharmacogenomics (Lond.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Allegrini, Giacomo; Coltelli, Luigi; Orlandi, Paola G.; Fontana, Andrea O.; Camerini, Andrea; Ferro, Antonella; Cazzaniga, Marina; Casadei, Virginia; Lucchesi, Sara; Bona, Eleonora; Di Lieto, Marco; Pazzagli, Ilaria; Villa, Federica; Amoroso, Domenico; Scalese, Marco U.; Arrighi, Giada; Molinaro, Sabrina; Fioravanti, Anna; Finale, Chiara; Triolo, Renza; Di Desidero, Teresa; Donati, Sara; Marcucci, Lorenzo; Goletti, Orlando; Del Re, Marzia; Salvadori, Barbara; Ferrarini, Ilaria; Danesi, Romano; Falcone, Alfredo; Bocci, Guido (literal)
Pagina inizio
  • 1985 (literal)
Pagina fine
  • 1999 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/record/display.url?eid=2-s2.0-84919789715&origin=inward (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 16 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Pontedera Hospital; Universita di Pisa; Azienda Ospedaliera-Universitaria Pisana; Versilia Hospital; Ospedale S. Chiara; Medical Oncology Unit; Azienda Ospedaliera San Salvatore di Pesaro; Azienda USL 3; S. Cosma and Damiano Hospital; Istituto di Fisiologia Clinica del CNR; Istituto Toscano Tumori (literal)
Titolo
  • Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab (literal)
Abstract
  • Aim: To investigate pharmacogenetic interactions among VEGF-A, VEGFR-2, IL-8, HIF-1?, EPAS-1 and TSP-1 SNPs and their role on progression-free survival in a population of metastatic breast cancer patients treated with bevacizumab in combination with first-line paclitaxel. Patients & methods: Analyses were performed on germline DNA obtained from blood samples and SNPs were investigated by real-time polymerase chain reaction technique. The multifactor dimensionality reduction methodology was applied to investigate the interaction between SNPs. Results: One hundred and thirteen patients were enrolled from eight Italian Oncology Units (clinicaltrial.gov: NCT01935102). The multifactor dimensionality reduction software provided two pharmacogenetic interaction profiles consisting of the combination between specific VEGFR-2 rs11133360 and IL-8 rs4073 genotypes. The median progression-free survival was 14.1 months (95% CI: 11.4-16.8) and 10.2 months (95% CI: 8.8-11.5) for the favorable and the unfavorable genetic profile, respectively (HR: 0.44, 95% CI: 0.29-0.66, p < 0.0001). Conclusion: The pharmacogenetic statistical interaction between VEGFR-2 rs11133360 and IL-8 rs4073 genotypes may identify a population of patients with a better outcome. (literal)
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