http://www.cnr.it/ontology/cnr/individuo/prodotto/ID319389
Nanoengineered Surfaces for Focal Adhesion Guidance Trigger Mesenchymal Stem Cell Self-Organization and Tenogenesis (Articolo in rivista)
- Type
- Label
- Nanoengineered Surfaces for Focal Adhesion Guidance Trigger Mesenchymal Stem Cell Self-Organization and Tenogenesis (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Alternative label
Maria Iannone,+,? Maurizio Ventre,+,? Lucia Formisano,+,? Laura Casalino,§ Eduardo J. Patriarca,§ and Paolo A. Netti (2015)
Nanoengineered Surfaces for Focal Adhesion Guidance Trigger Mesenchymal Stem Cell Self-Organization and Tenogenesis
in Nanoletters
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Maria Iannone,+,? Maurizio Ventre,+,? Lucia Formisano,+,? Laura Casalino,§ Eduardo J. Patriarca,§ and Paolo A. Netti (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://pubs.acs.org/doi/abs/10.1021/nl503737k (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- +Center for Advanced Biomaterials for Healthcare@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Naples, Italy
?Department of Chemical, Materials and Industrial Production Engineering and Interdisciplinary Research Centre on Biomaterials, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy
§Stem Cell Fate Laboratory, Institute of Genetics and Biophysics \"A. Buzzati-Traverso\", National Research Council, Via Castellino 111, 80131 Naples, Italy (literal)
- Titolo
- Nanoengineered Surfaces for Focal Adhesion Guidance Trigger Mesenchymal Stem Cell Self-Organization and Tenogenesis (literal)
- Abstract
- The initial conditions for morphogenesis trigger a cascade of events that ultimately dictate structure and functions of tissues and organs. Here we report that surface nanopatterning can control the initial assembly of focal adhesions, hence guiding human mesenchymal stem cells (hMSCs) through the process of self-organization and differentiation. This process self-sustains, leading to the development of macroscopic tissues with molecular profiles and microarchitecture reminiscent of embryonic tendons. Therefore, material surfaces can be in principle engineered to set off the hMSC program toward tissuegenesis in a deterministic manner by providing adequate sets of initial environmental conditions. (literal)
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