Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• M. Catauro, M.G. Raucci, D. De Marco, L. Ambrosio (2006)
  Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Catauro, M.G. Raucci, D. De Marco, L. Ambrosio (literal)

Pagina inizio

• 340 (literal)

Pagina fine

• 350 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 77 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• M. Catauro (Department of Aerospace and Mechanical Engineering, Second University of Naples,81031 Aversa (CE), Italy D. De Marco (Department of Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio, 80125 Naples, Italy) (literal)

Titolo

• Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing (literal)

Abstract

• Poly(µ -caprolactone) (PCL 6, 12, and 24 wt %) and titanium (TiO2) organic–inorganic hybrid materials have been synthesized by the sol– gel method from a multicomponent solution containing titanium butoxide, poly( µ-caprolactone) (PCL), water, and chloroform (CHCl3). Sodium ampicillin was incorporated in the hybrid material to verify the effect as local controlled drug delivery system. The structure of a hybrid materials interpenetrating network is realized by hydrogen bonds between Ti-OH group (Hdonator) in the sol– gel intermediate species and carboxylic group (H-acceptor) in the repeating units of the polymer. The presence of hydrogen bonds between organic/inorganic components of the hybrid materials was proved by FTIR analysis. The morphology of the hybrid materials was studied by scanning electron microscope (SEM). The structure of a molecular level dispersion has been disclosed by atomic force microscope (AFM), pore size distribution and surface measurements. The bioactivity of the synthesized hybrid materials has been showed by the formation of a layer of hydroxyapatite on the surface of TiO2/PCL samples soaked in a .uid simulating the composition of the human blood plasma. The amount of sodium ampicillin released has been detected by UV–vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. HPLC analysis has also been taken to ensure the integrity of ampicillin after the synthetic treatment. (literal)

Prodotto di

• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)
• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• Maria Grazia Raucci (Unità di personale esterno)
• LUIGI AMBROSIO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR di

• LUIGI AMBROSIO (Unità di personale interno)
• Maria Grazia Raucci (Unità di personale esterno)

Insieme di parole chiave di

• Parole chiave di "Release kinetics of ampicillin, characterization and bioactivity of TiO2/PCL hybrid materials synthesized by sol– gel processing" (Insieme di parole chiave)