Induction of directional sprouting angiogenesis by matrix gradients (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Induction of directional sprouting angiogenesis by matrix gradients (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Borselli, C., Oliviero, O., Battista, S., Ambrosio, L., and Netti, P.A. (2007)
  Induction of directional sprouting angiogenesis by matrix gradients
  in Journal of biomedical materials research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Borselli, C., Oliviero, O., Battista, S., Ambrosio, L., and Netti, P.A. (literal)

Pagina inizio

• 297 (literal)

Pagina fine

• 305 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 80A (literal)

Rivista

• Journal of biomedical materials research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Borselli, C., Oliviero, O., Battista,Netti, P.A., CRIB, Università di Napoli Federico II, Piazzale Tecchio 80, 80125 Naples, Italy (literal)

Titolo

• Induction of directional sprouting angiogenesis by matrix gradients (literal)

Abstract

• The fate of any tissue engineering implant relies upon an adequate oxygen and nutrients supply throughout the cellular construct and, hence, by the ability of the scaffold to induce and guide vascular ingrowth. However, implant vascularization is usually an uncontrolled process that takes several weeks. In this work, we assessed the feasibility of controlling vascular sprout rate and direction within three-dimensional collagen–hyaluronic acid semiinterpenetrated networks by modulating the spatial distribution of the matricellular cues. Results indicated that increasing amount of hyaluronic acid (HA) within the matrix led to a progressive inhibition of sprouting. In HArich matrices, the sprout number and the propagation rate showed a 2.7- and 4-fold reduction, respectively, compared to collagen matrices. Furthermore, by creating HA gradients within the collagen network, we were able to direct and enhance the sprouting rate. This study provides an experimental platform for controlling vascularization of engineered tissues. (literal)

Prodotto di

• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• SABRINA BATTISTA (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Induction of directional sprouting angiogenesis by matrix gradients" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Ruolo delle proteine cromatiniche nella tumorigenesi (SV.P15.001.002) (Modulo)
• http://www.cnr.it/ontology/cnr/individuo/modulo/ID2350

Autore CNR di

• LUIGI AMBROSIO (Unità di personale interno)
• SABRINA BATTISTA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomedical materials research (Rivista)

Insieme di parole chiave di

• Keywords of "Induction of directional sprouting angiogenesis by matrix gradients" (Insieme di parole chiave)