Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain (Articolo in rivista) (literal)

Anno

• 1996-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0028-3908(96)00067-6 (literal)

Alternative label

• Barbaccia, ML; Roscetti, G; Trabucchi, M; Purdy, RH; Mostallino, MC; Perra, C; Concas, A; Biggio, G (1996)
  Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain
  in Neuropharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Barbaccia, ML; Roscetti, G; Trabucchi, M; Purdy, RH; Mostallino, MC; Perra, C; Concas, A; Biggio, G (literal)

Pagina inizio

• 1299 (literal)

Pagina fine

• 1305 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• Neuropharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9-10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Medicine, University of Rome Tor Vergata, Rome; Department of Psychiatry, University of California, San Diego, California; Department of Experimental Biology, University of Cagliari, Cagliari (literal)

Titolo

• Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain (literal)

Abstract

• Isoniazid (375 mg/kg, s.c.), a drug that decreases GABA(A) receptor-mediated transmission, elicited a time-dependent increase of neuroactive steroid (pregnenolone, progesterone and allotetrahydro-deoxycorticosterone) concentrations in rat brain and plasma. This treatment also time-dependently increased the plasma concentration of corticosterone. Brain and plasma neuroactive steroid levels peaked between 40 and 120 min after isoniazid administration, respectively, and returned to control values by 5 hr. Acute foot shock stress mimicked the effect of isoniazid by increasing in a time-dependent manner the same neuroactive steroids both in brain and plasma. Abecarnil (0.3 mg/kg, i.p.), a beta-carboline derivative with anxiolytic properties, antagonized the effect of both isoniazid and foot shock on brain and plasma neuroactive steroids and on plasma corticosterone level. These data indicate that an inhibition of central GABAergic transmission enhances the concentrations of THDOC and its precursors pregnenolone and progesterone in the rat brain and plasma as well as the plasma levels of corticosterone. This finding suggests that GABA exerts a tonic inhibitory action on the mechanisms involved in the regulation of the synthesis and release of these neuroactive steroids in the central nervous system and plasma. Copyright (C) 1996 Elsevier Science Ltd. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• MARIA CRISTINA MOSTALLINO (Persona)

Insieme di parole chiave

• Parole chiave di "Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MOSTALLINO (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuropharmacology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain" (Insieme di parole chiave)