Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil (Articolo in rivista) (literal)

Anno

• 1996-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/0091-3057(95)02133-7 (literal)

Alternative label

• Barbaccia, ML; Concas, A; Roscetti, G; Bolacchi, F; Mostallino, MC; Purdy, RH; Biggio, G (1996)
  Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil
  in Pharmacology, biochemistry and behavior
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Barbaccia, ML; Concas, A; Roscetti, G; Bolacchi, F; Mostallino, MC; Purdy, RH; Biggio, G (literal)

Pagina inizio

• 205 (literal)

Pagina fine

• 210 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 54 (literal)

Rivista

• Pharmacology, biochemistry and behavior (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Medicine, University of Rome Tor Vergata, Rome; Department of Experimental Biology, University of Cagliari, Cagliari; Department of Psychiatry, University of California, San Diego (literal)

Titolo

• Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil (literal)

Abstract

• Acute foot shock stress elicits a selective and time-dependent increase of neuroactive steroid (pregnenolone, progesterone, allotetrahydrodeoxycorticosterone) concentrations in rat brain cortex, accompanied by a marked increase of plasma corticosterone. The brain cortical neuroactive steroid levels peaked between 10 and 30 min poststress and returned to control values by 2 h. Abecarnil (0.3 mg/kg, IP), a beta-carboline derivative with anxiolytic properties, completely antagonized the effect of foot shock on brain cortical neuroactive steroids. A single administration of the anxiogenic beta-carboline FG 7142 (15 mg/kg, IP), in contrast, mimicked the effect of foot shock. These data support the hypothesis for the existence of a functional relationship between brain neuroactive steroid concentrations and GABA(A) receptor function/emotional state of the animal. (literal)

Prodotto di

• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MARIA CRISTINA MOSTALLINO (Persona)

Insieme di parole chiave

• Keywords of "Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MOSTALLINO (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacology, biochemistry and behavior (Rivista)

Insieme di parole chiave di

• Keywords of "Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil" (Insieme di parole chiave)