Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.imlet.2014.08.010 (literal)

Alternative label

• Mauri, Pierluigi; Riccio, Anna Maria; Rossi, Rossana; Di Silvestre, Dario; Benazzi, Louise; De Ferrari, Laura; Dal Negro, Roberto Walter; Holgate, Stephen T.; Canonica, Giorgio Walter (2014)
  Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients
  in Immunology letters
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mauri, Pierluigi; Riccio, Anna Maria; Rossi, Rossana; Di Silvestre, Dario; Benazzi, Louise; De Ferrari, Laura; Dal Negro, Roberto Walter; Holgate, Stephen T.; Canonica, Giorgio Walter (literal)

Pagina inizio

• 2 (literal)

Pagina fine

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 162 (literal)

Rivista

• Immunology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Inst Biomed Technol ITB CNR; University of Genoa; CMS; University of Southampton (literal)

Titolo

• Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients (literal)

Abstract

• Asthma is a chronic inflammatory disease. Reticular basement membrane (RBM) thickening is considered feature of airway remodelling (AR) particularly in severe asthma (SA). Omalizumab, mAb to IgE is effective in SA and can modulate AR. Herein we describe protein profiles of bronchial biopsies to detect biomarkers of anti-IgE effects on AR and to explain potential mechanisms/pathways. We defined the bronchial biopsy protein profiles, before and after treatment. Unsupervised clustering of baseline proteomes resulted in very good agreement with the morphometric analysis of AR. Protein profiles of omalizumab responders (ORs) were significantly different from those of non-omalizumab responders (NORs). The major differences between ORs and NORs lied to smooth muscle and extra cellular matrix proteins. Notably, an IgE-binding protein (galectin-3) was reliable, stable and predictive biomarker of AR modulation. Omalizumab down-regulated bronchial smooth muscle proteins in SA. These findings suggest that omalizumab may exert disease-modifying effects on remodelling components. (C) 2014 The Authors. Published by Elsevier B.V. (literal)

Prodotto di

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Autore CNR

• PIETRO LUIGI MAURI (Unità di personale interno)
• LOUISE BENAZZI (Persona)
• DARIO DI SILVESTRE (Persona)
• ROSSANA ROSSI (Persona)

Insieme di parole chiave

• Keywords of "Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• LOUISE BENAZZI (Persona)
• PIETRO LUIGI MAURI (Unità di personale interno)
• DARIO DI SILVESTRE (Persona)
• ROSSANA ROSSI (Persona)

Prodotto

• ProteoMetabolomica - Sviluppo ed applicazione della LC-MS/MS per lo studio di proteine e metaboliti (PM.P06.008.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Immunology letters (Rivista)

Insieme di parole chiave di

• Keywords of "Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients" (Insieme di parole chiave)