http://www.cnr.it/ontology/cnr/individuo/prodotto/ID317119
INTERACTION OF URIDINE WITH GAMMA AMINO BUTYRIC-ACID BINDING SITES IN CEREBELLAR MEMBRANES OF THE RAT (Articolo in rivista)
- Type
- Label
- INTERACTION OF URIDINE WITH GAMMA AMINO BUTYRIC-ACID BINDING SITES IN CEREBELLAR MEMBRANES OF THE RAT (Articolo in rivista) (literal)
- Anno
- 1983-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/BF00964155 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- GUARNERI P; GUARNERI R; MOCCIARO C; PICCOLI F (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- SI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR - IBIM Istituto di Biomedicina e Immunologia Molecolare \"Alberto Monroy\" Palermo (literal)
- Titolo
- INTERACTION OF URIDINE WITH GAMMA AMINO BUTYRIC-ACID BINDING SITES IN CEREBELLAR MEMBRANES OF THE RAT (literal)
- Abstract
- The effect of uridine, a postulated anticonvulsant agent, on GABA receptors was investigated. Uridine inhibits [3H]GABA binding to rat cerebellar buffer-washed membranes. Pretreatment of the membranes with Triton X-100 increases the effect of uridine on GABA-binding. The Scatchard analysis reveals that both high and low affinities of GABA for its receptors are affected by 1 mM uridine, while the apparent number of binding sites remains unchanged. The ability of uridine to interact competitively with GABA binding sites, also examined by the Lineweaver-Burk analysis, suggests a possible mechanism of action of this anticonvulsant agent, thus including it among those compounds characterized by a GABAergic agonist activity. (literal)
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- Autore CNR
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