Fully electronic DNA hybridization detection by a standard CMOS biochip (Articolo in rivista)

Type
Label
  • Fully electronic DNA hybridization detection by a standard CMOS biochip (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Barbaro, M; Bonfiglio, A; Raffo, L; Alessandrini, A; Facci, P; Barak, I (2006)
    Fully electronic DNA hybridization detection by a standard CMOS biochip
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Barbaro, M; Bonfiglio, A; Raffo, L; Alessandrini, A; Facci, P; Barak, I (literal)
Pagina inizio
  • 41 (literal)
Pagina fine
  • 46 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 118 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Cagliari, Dept Elect & Elect Engn, I-09123 Cagliari, Italy; INFM, CNR, S3, Modena, Italy; Slovak Acad Sci, Inst Mol Biol, Bratislava 84251, Slovakia; CNISM, Consorzio Nazl Interuniv Sci Mat, Unita Cagliari, Cagliari, Italy (literal)
Titolo
  • Fully electronic DNA hybridization detection by a standard CMOS biochip (literal)
Abstract
  • A novel solid-state biosensor for label-free detection of DNA hybridization is presented. The new device is realized in a standard CMOS process, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on the field-effect of the intrinsic negative electric charge of DNA molecules which modulates the threshold voltage of a floating-gate MOS transistor. A fluid cell was developed for delivering DNA samples on the active surface of the chip. The device has an integrated, individual counter-electrode, so dry measurements are possible increasing lifetime of the chip and speeding up the experiment. Successful measurements on a first prototype of the chip, hosting 16 sensors individually addressable, are provided as proof of concept. (c) 2006 Elsevier B.V. All rights reserved. (literal)
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