Biomedical applications of a superabsorbent hydrogels for body water elimination in the treatment of edemas (Articolo in rivista)

Type
Label
  • Biomedical applications of a superabsorbent hydrogels for body water elimination in the treatment of edemas (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sannino A. 1, Esposito A. 2, De Rosa A. 2, Cozzolini A. 3, Ambrosio L. 4, Nicolais L. 4 (2003)
    Biomedical applications of a superabsorbent hydrogels for body water elimination in the treatment of edemas
    in Journal of biomedical materials research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sannino A. 1, Esposito A. 2, De Rosa A. 2, Cozzolini A. 3, Ambrosio L. 4, Nicolais L. 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • The results obtained by an interdisciplinary research permit to obtain a superabsorbent biocompatible hydrogel for the treatment of oedemas and others applications. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 67A (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • 14 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • A superabsorbent cellulose derivatives able to absorb large amount of water and water solutions, has been investigated as system of body water elimination to be used for the treatment of oedemas. Hydrogels have been synthesized starting from water solutions of Carboxymethilcellulose Sodium Salt (CMCNa) and Hydroxyethilcellulose (HEC), chemically crosslinked with Divinylsulphone (DVS). Polyelectrolyte hydrogels displayed high sensitivity in sorption capacity to variation of the ionic strength and pH of the external solution, which is a key parameter for the application under investigation. The results obtained from the biocompatibility studies carried out in this work are consistent with the hypothesis that this gel may represent an alternative to diuretic therapies in those pathologic conditions in which oedemas occur. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 University of Lecce 2 Second University of Naples, 3 University of Naples ‘Federico II’, 4 IMCB-CNR (literal)
Titolo
  • Biomedical applications of a superabsorbent hydrogels for body water elimination in the treatment of edemas (literal)
Abstract
  • A novel system of body water elimination to be used for the treatment of oedemas, based on superabsorbent cellulose derivatives able to absorb large amount of water and water solutions, has been investigated. Hydrogels have been synthesized starting from water solutions of Carboxymethilcellulose Sodium Salt (CMCNa) and Hydroxyethilcellulose (HEC), chemically crosslinked with Divinylsulphone (DVS). Polyelectrolyte hydrogels displayed high sensitivity in sorption capacity to variation of the ionic strength and pH of the external solution, which is a key parameter for the application under investigation. Furthermore, swelling properties have been modulated acting on the degree of crosslinking of the macromolecular network, and a direct method for the measurement of this parameter based on NMR solid state analysis has been provided. The hydrogel biocompatibility has been studied in terms of its capacity either to induce Nitric Oxide and lactate dehydrogenase release by macrophages or to influence their viability. The eventual release of toxic substances from the hydrogel was also investigated using Swiss 3T3 fibroblasts. The results obtained from the biocompatibility studies carried out in this work are consistent with the hypothesis that this gel may represent an alternative to diuretic therapies in those pathologic conditions in which oedemas occur. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it