Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmc.2012.09.023 (literal)

Alternative label

• Monasterolo, Claudio and Ballestri, Marco and Sotgiu, Giovanna and Guerrini, Andrea and Dambruoso, Paolo and Sparnacci, Katia and Laus, Michele and Cesare, Michelandrea De and Pistone, Assunta and Beretta, Giovanni Luca and Zunino, Franco and Benfenati, Valentina and Varchi, Greta (2012)
  Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application.
  in Bioorganic & medicinal chemistry (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Monasterolo, Claudio and Ballestri, Marco and Sotgiu, Giovanna and Guerrini, Andrea and Dambruoso, Paolo and Sparnacci, Katia and Laus, Michele and Cesare, Michelandrea De and Pistone, Assunta and Beretta, Giovanni Luca and Zunino, Franco and Benfenati, Valentina and Varchi, Greta (literal)

Pagina inizio

• 6640 (literal)

Pagina fine

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/23043726 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• Bioorganic & medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 22 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto per la Sintesi Organica e la Fotoreattività, 'CNR-I.S.O.F.', Area della Ricerca di Bologna, via P. Gobetti 101, 40129 Bologna, Italy Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy Istituto per lo studio dei Materiali Nanostrutturati, ISMN Area della Ricerca di Bologna, via P. Gobetti 101, 40129 Bologna, Italy Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale 'A. Avogadro', Viale T. Michel 11, 15100 Alessandria, Italy (literal)

Titolo

• Sulfonates-PMMA nanoparticles conjugates: A versatile system for multimodal application. (literal)

Abstract

• We report herein the viability of a novel nanoparticles (NPs) conjugated system, namely the attachment, based on ionic and hydrophobic interactions, of different sulfonated organic salts to positively charged poly(methylmethacrylate) (PMMA)-based core-shell nanoparticles (EA0) having an high density of ammonium groups on their shells. In this context three different applications of the sulfonates@EA0 systems have been described. In detail, their ability as cytotoxic drugs and pro-drugs carriers was evaluated in vitro on NCI-H460 cell line and in vivo against human ovarian carcinoma IGROV-1 cells. Besides, 8-hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt (HPTS) was chosen for NPs loading, and its internalization as bioimaging probe was evaluated on Hep G2 cells. Overall, the available data support the interest for these PMMA NPs@sulfonates systems as a promising formulation for theranostic applications. In vivo biological data strongly support the potential value of these core-shell NPs as delivery system for negatively charged drugs or biologically active molecules. Additionally, we have demonstrated the ability of these PMMA core-shell nanoparticles to act as efficient carriers of fluorophores. In principle, thanks to the high PMMA NPs external charge density, sequential and very easy post-loading of different sulfonates is achievable, thus allowing the preparation of nanocarriers either with bi-modal drug delivery behaviour or as theranostic systems. (literal)

Prodotto di

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)

Autore CNR

• VALENTINA BENFENATI (Unità di personale esterno)
• MARCO BALLESTRI (Persona)
• GIOVANNA SOTGIU (Persona)
• ANDREA GUERRINI (Persona)
• GRETA VARCHI (Unità di personale interno)
• ASSUNTA PISTONE (Unità di personale esterno)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR di

• GRETA VARCHI (Unità di personale interno)
• MARCO BALLESTRI (Persona)
• GIOVANNA SOTGIU (Persona)
• ANDREA GUERRINI (Persona)
• VALENTINA BENFENATI (Unità di personale esterno)
• ASSUNTA PISTONE (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry (Rivista)