EMILIN1/alpha9beta1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• EMILIN1/alpha9beta1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1128/MCB.00872-13 (literal)

Alternative label

• Danussi C, Del Bel Belluz L, Pivetta E, Modica TM, Muro A, Wassermann B, Doliana R, Sabatelli P, Colombatti A, Spessotto P. (2013)
  EMILIN1/alpha9beta1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance.
  in Molecular and cellular biology (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Danussi C, Del Bel Belluz L, Pivetta E, Modica TM, Muro A, Wassermann B, Doliana R, Sabatelli P, Colombatti A, Spessotto P. (literal)

Pagina inizio

• 4381 (literal)

Pagina fine

• 4394 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Molecular and cellular biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 22 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Experimental Oncology 2, CRO, IRCCS, National Cancer Institute, Aviano (PN), Italy; International Centre for Genetic Engineering and Biotechnology, Trieste, Italy; CNR-National Research Council of Italy, IGM-IOR, Bologna, Italy; SC Laboratory of Muscoloskeletal Cell Biology, IOR, Bologna, Italy; Department of Medical and Biomedical Sciences, University of Udine, Udine, Italye, MATI (Microgravity, Ageing, Training, Immobility) Excellence Center, University of Udine, Udine, Italy (literal)

Titolo

• EMILIN1/alpha9beta1 Integrin Interaction Is Crucial in Lymphatic Valve Formation and Maintenance. (literal)

Abstract

• Lymphatic vasculature plays a crucial role in the maintenance of tissue interstitial fluid balance. The role of functional collecting lymphatic vessels in lymph transport has been recently highlighted in pathologies leading to lymphedema, for which treatments are currently unavailable. Intraluminal valves are of paramount importance in this process. However, valve formation and maturation have not been entirely elucidated yet, in particular, the role played by the extracellular matrix (ECM). We hypothesized that EMILIN1, an ECM multidomain glycoprotein, regulates lymphatic valve formation and maintenance. Using a mouse knockout model, we show that in the absence of EMILIN1, mice exhibit defects in lymphatic valve structure and in lymph flow. By applying morphometric in vitro and in vivo functional assays, we conclude that this impaired phenotype depends on the lack of ?9?1 integrin engagement, the specific lymphatic endothelial cell receptor for EMILIN1, and the ensuing derangement of cell proliferation and migration. Our data demonstrate a fundamental role for EMILIN1-integrin ?9 interaction in lymphatic vasculature, especially in lymphatic valve formation and maintenance, and underline the importance of this ECM component in displaying a regulatory function in proliferation and acting as a \"guiding\" molecule in migration of lymphatic endothelial cells. (literal)

Prodotto di

• Patogenesi delle malattie degenerative muscolo-scheletriche (ME.P05.014.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• PATRIZIA SABATELLI (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Patogenesi delle malattie degenerative muscolo-scheletriche (ME.P05.014.001) (Modulo)

Autore CNR di

• PATRIZIA SABATELLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular and cellular biology (Rivista)