http://www.cnr.it/ontology/cnr/individuo/prodotto/ID314742
Steps and routes of HCV infection: the great promise of new anti-viral targets (Articolo in rivista)
- Type
- Label
- Steps and routes of HCV infection: the great promise of new anti-viral targets (Articolo in rivista) (literal)
- Anno
- 2015-01-01T00:00:00+01:00 (literal)
- Alternative label
Annalisa Crema, (1) Antonio Ponzetto, (2) Massimo Clementi, (3) and Guido Carloni, (1) (2015)
Steps and routes of HCV infection: the great promise of new anti-viral targets
in Current drug targets. CNS & neurological disorders
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Annalisa Crema, (1) Antonio Ponzetto, (2) Massimo Clementi, (3) and Guido Carloni, (1) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Accepted Dicembre 2014 (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- (1) Institute of Translational Pharmacology, National Research Council, Tor Vergata, Rome, Italy
(2) Dept. Internal Medicine, University of Torino, Turin, Italy
(3) Laboratory of Microbiology and Virology, University Vita-Salute San Raffaele, Milan, Italy (literal)
- Titolo
- Steps and routes of HCV infection: the great promise of new anti-viral targets (literal)
- Abstract
- SUMMARY
A major breakthrough in understanding the steps and signalling that drives the HCV to reach a full life-cycle has been achieved by in vitro models that have facilitated elevated virus production, resulting in the discovery of pathways and factors involved in virus entry, translation and replication. The HCV enters host cells through binding of its envelope glycoproteins to cell receptors, followed by clathrin-mediated endocytosis and fusion with cell membranes, leading to virus uncoating and cell entry. This chain of events is mediated by sequential involvement of different co-receptors, for example, SR-B1, CD81 and the tight-junction proteins- claudin and occludin. HCV RNA replication and translation are coupled processes, requiring cooperation of replicase, helicase and other viral proteins with cell-regulatory factors. Virion packaging and release are highly targetable steps, although they require greater in-depth investigation. The HCV-immune response appears to be fairly ineffective, and neutralizing antibodies that inhibit E2-CD81 binding are unable to resolve infection. HCV-transmission through cell-to-cell contact has been implicated in the evolution of chronic infection. In particular, CD81-dependency and the role of other co-factors involved in entry in cell-to-cell infection, as well as virus escape from host-neutralization still require confirmation. To highlight viral and cell mechanisms implicated in HCV-infection, we review here some of the major discoveries that have been made, from virus entry to its release from infected cells, in understanding the HCV host-cell interplay, which may help in defining new molecular targets to provide therapeutic antiviral strategies. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi