The Molecular Genetic Architecture of Self-Employment (Articolo in rivista)

Type
Label
  • The Molecular Genetic Architecture of Self-Employment (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0060542 (literal)
Alternative label
  • van der Loos, Matthijs J. H. M.; Rietveld, Cornelius A.; Eklund, Niina; Koellinger, Philipp D.; Rivadeneira, Fernando; Abecasis, Goncalo R.; Ankra-Badu, Georgina A.; Baumeister, Sebastian E.; Benjamin, Daniel J.; Biffar, Reiner; Blankenberg, Stefan; Boomsma, Dorret I.; Cesarini, David; Cucca, Francesco; de Geus, Eco J. C.; Dedoussis, George; Deloukas, Panos; Dimitriou, Maria; Eiriksdottir, Guony; Eriksson, Johan; Gieger, Christian; Gudnason, Vilmundur; Hoehne, Birgit; Holle, Rolf; Hottenga, Jouke-Jan; Isaacs, Aaron; Jarvelin, Marjo-Riitta; Johannesson, Magnus; Kaakinen, Marika; Kahonen, Mika; Kanoni, Stavroula; Laaksonen, Maarit A.; Lahti, Jari; Launer, Lenore J.; Lehtimaki, Terho; Loitfelder, Marisa; Magnusson, Patrik K. E.; Naitza, Silvia; Oostra, Ben A.; Perola, Markus; Petrovic, Katja; Quaye, Lydia; Raitakari, Olli; Ripatti, Samuli; Scheet, Paul; Schlessinger, David; Schmidt, Carsten O.; Schmidt, Helena; Schmidt, Reinhold; Senft, Andrea; Smith, Albert V.; Spector, Timothy D.; Surakka, Ida; Svento, Rauli; Terracciano, Antonio; Tikkanen, Emmi; van Duijn, Cornelia M.; Viikari, Jorma; Voelzke, Henry; Wichmann, H. -Erich; Wild, Philipp S.; Willems, Sara M.; Willemsen, Gonneke; van Rooij, Frank J. A.; Groenen, Patrick J. F.; Uitterlinden, Andre G.; Hofman, Albert; Thurik, A. Roy (2013)
    The Molecular Genetic Architecture of Self-Employment
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • van der Loos, Matthijs J. H. M.; Rietveld, Cornelius A.; Eklund, Niina; Koellinger, Philipp D.; Rivadeneira, Fernando; Abecasis, Goncalo R.; Ankra-Badu, Georgina A.; Baumeister, Sebastian E.; Benjamin, Daniel J.; Biffar, Reiner; Blankenberg, Stefan; Boomsma, Dorret I.; Cesarini, David; Cucca, Francesco; de Geus, Eco J. C.; Dedoussis, George; Deloukas, Panos; Dimitriou, Maria; Eiriksdottir, Guony; Eriksson, Johan; Gieger, Christian; Gudnason, Vilmundur; Hoehne, Birgit; Holle, Rolf; Hottenga, Jouke-Jan; Isaacs, Aaron; Jarvelin, Marjo-Riitta; Johannesson, Magnus; Kaakinen, Marika; Kahonen, Mika; Kanoni, Stavroula; Laaksonen, Maarit A.; Lahti, Jari; Launer, Lenore J.; Lehtimaki, Terho; Loitfelder, Marisa; Magnusson, Patrik K. E.; Naitza, Silvia; Oostra, Ben A.; Perola, Markus; Petrovic, Katja; Quaye, Lydia; Raitakari, Olli; Ripatti, Samuli; Scheet, Paul; Schlessinger, David; Schmidt, Carsten O.; Schmidt, Helena; Schmidt, Reinhold; Senft, Andrea; Smith, Albert V.; Spector, Timothy D.; Surakka, Ida; Svento, Rauli; Terracciano, Antonio; Tikkanen, Emmi; van Duijn, Cornelia M.; Viikari, Jorma; Voelzke, Henry; Wichmann, H. -Erich; Wild, Philipp S.; Willems, Sara M.; Willemsen, Gonneke; van Rooij, Frank J. A.; Groenen, Patrick J. F.; Uitterlinden, Andre G.; Hofman, Albert; Thurik, A. Roy (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 8 (literal)
Rivista
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  • 15 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Erasmus University Rotterdam; Erasmus University Rotterdam; University of Helsinki; Finland National Institute for Health & Welfare; Erasmus University Rotterdam; University of Michigan; Kings College London; Univ Med Greifswald; Cornell University; Ernst Moritz Arndt Universitat Greifswald; University of Hamburg; VU University Amsterdam; New York University; Consiglio Nazionale delle Ricerche (CNR); Harokopio University Athens; Wellcome Trust Sanger Institute; Iceland Heart Assoc; Finland National Institute for Health & Welfare; University of Helsinki; Folkhalsan Res Ctr; Helsinki University Central Hospital; Vaasa Cent Hosp; Helmholtz Association; University of Iceland; Helmholtz Association; Helmholtz Association; Erasmus University Rotterdam; VU University Amsterdam; University of Oulu; University of Oulu; Finland National Institute for Health & Welfare; Imperial College London; Stockholm School of Economics; University of Tampere; University of Tampere; Finland National Institute for Health & Welfare; University of Helsinki; National Institute on Aging (NIA); Tampere Univ Hosp; University of Tampere; Medical University of Graz; Karolinska Institutet; Erasmus University Rotterdam; University of Tartu; Gen Hosp; Medical University of Graz; University of Turku; University of Turku; UTMD Anderson Cancer Center; National Institute on Aging (NIA); Medical University of Graz; University of Kiel; University of Oulu; Florida State University; University of Turku; University of Turku; Helmholtz Association; University of Munich; University of Munich; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Erasmus University Rotterdam; Panteia; GSCM Montpellier Business Sch (literal)
Titolo
  • The Molecular Genetic Architecture of Self-Employment (literal)
Abstract
  • Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (sigma(2)(g)/sigma(2)(P) = 25%, h(2) = 55%). However, a meta-analysis of genome-wide association studies across sixteen studies comprising 50,627 participants did not identify genome-wide significant SNPs. 58 SNPs with p<10(-5) were tested in a replication sample (n = 3,271), but none replicated. Furthermore, a gene-based test shows that none of the genes that were previously suggested in the literature to influence entrepreneurship reveal significant associations. Finally, SNP-based genetic scores that use results from the meta-analysis capture less than 0.2% of the variance in self-employment in an independent sample (p >= 0.039). Our results are consistent with a highly polygenic molecular genetic architecture of self-employment, with many genetic variants of small effect. Although self-employment is a multi-faceted, heavily environmentally influenced, and biologically distal trait, our results are similar to those for other genetically complex and biologically more proximate outcomes, such as height, intelligence, personality, and several diseases. (literal)
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