Eosinophilic phenotypes of overlapping respiratory diseases in an Italian general population sample (Abstract in rivista)

Type
Label
  • Eosinophilic phenotypes of overlapping respiratory diseases in an Italian general population sample (Abstract in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sonia Cerrai, Marzia Simoni, Sara Maio, Giuseppe Sarno, Sandra Baldacci, Anna Angino, Franca Martini, Francesco Pistelli, Laura Carrozzi and Giovanni Viegi (2014)
    Eosinophilic phenotypes of overlapping respiratory diseases in an Italian general population sample
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sonia Cerrai, Marzia Simoni, Sara Maio, Giuseppe Sarno, Sandra Baldacci, Anna Angino, Franca Martini, Francesco Pistelli, Laura Carrozzi and Giovanni Viegi (literal)
Pagina inizio
  • 4084 (literal)
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  • ERS Congress 2014, European Respiratory Society (ERS) International Congress 2014, 06 - 10 September 2014 / Germany, Bayern, Munich (literal)
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  • 44 (suppl. 58) (literal)
Rivista
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  • 1 (literal)
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  • Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Epidemiology, Pisa, Italy; Institute of BioMedicine and Molecular Immunology \"A. Monroy\", CNR, Palermo, Italy. (literal)
Titolo
  • Eosinophilic phenotypes of overlapping respiratory diseases in an Italian general population sample (literal)
Abstract
  • Aim: to quantify the distribution of overlapping diagnosis of Asthma (A), Chronic Bronchitis (CB) and Emphysema (E), stratifying by blood eosinophilia (EOS+/EOS-). To evaluate the role of environmental/host risk factors for eosinophilic phenotypes of A and COPD (CB+E). Methods: 1919 subjects (8-88 yrs, 49% males) enrolled in an Italian cross-sectional study (1991-93), filled in a questionnaire on respiratory symptoms/diseases and risk factors and underwent a blood test. Eosinophil count is expressed as % of total leucocytes (EOS+ >3%). A double proportional Venn diagram is used to show the distribution of A, CB, E and their overlapping categories. A Multinomial Logistic Regression were run to assess the association of A or COPD eosinophilic phenotypes with gender, age, smoke, work exposure, eczema, rhinitis and diagnosis of asthma or COPD (Odd Ratio-OR, Confidence Interval-CI 95%). AsmaEOS+ and AsmaEOS- are associated with COPD (OR 5.1 vs 6.9) and rhinitis (6.3 vs 2.4); AsmaEOS+ is also associated with age<25 (3.1) and smoke (0.4).As for COPD, we pinpoint the association of COPDEOS+ and COPDEOS- with work exposure (3.3 vs 1.6) and the association of COPDEOS- with rhinitis (0.4). Conclusions: eosinophilic pattern is more frequent in young people and generally EOS+ subjects tend to be non smokers. The results confirm the expected overlap among respiratory diagnosis and show higher values in EOS- condition. (literal)
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