Genetic variability in the regulation of gene expression in ten regions of the human brain (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Genetic variability in the regulation of gene expression in ten regions of the human brain (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/nn.3801 (literal)

Alternative label

• Ramasamy, Adaikalavan; Trabzuni, Daniah; Guelfi, Sebastian; Varghese, Vibin; Smith, Colin; Walker, Robert; De, Tisham; Coin, Lachlan; de Silva, Rohan; Cookson, Mark R.; Singleton, Andrew B.; Hardy, John; Ryten, Mina; Weale, Michael E. (2014)
  Genetic variability in the regulation of gene expression in ten regions of the human brain
  in Nature neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ramasamy, Adaikalavan; Trabzuni, Daniah; Guelfi, Sebastian; Varghese, Vibin; Smith, Colin; Walker, Robert; De, Tisham; Coin, Lachlan; de Silva, Rohan; Cookson, Mark R.; Singleton, Andrew B.; Hardy, John; Ryten, Mina; Weale, Michael E. (literal)

Pagina inizio

• 1418 (literal)

Pagina fine

• 1428 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Nature neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Guy's & St Thomas' NHS Foundation Trust; University College London; King Faisal Specialist Hospital & Research Center; University of Edinburgh; Imperial College London; University of Queensland; National Institute on Aging (NIA) (literal)

Titolo

• Genetic variability in the regulation of gene expression in ten regions of the human brain (literal)

Abstract

• Germ-line genetic control of gene expression occurs via expression quantitative trait loci (eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions. We found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. We report cis-eQTL signals for 23.1% of catalogued genome-wide association study hits for adult-onset neurological disorders. The data set is publicly available via public data repositories and via http://www.braineac.org/. Our study increases our understanding of the regulation of gene expression in the human brain and will be of value to others pursuing functional follow-up of disease-associated variants. (literal)

Prodotto di

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR

• PAOLA FORABOSCO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR di

• PAOLA FORABOSCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature neuroscience (Rivista)