Prognostic significance of N-cadherin expression in oral squamous cell carcinoma (Articolo in rivista)

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  • Prognostic significance of N-cadherin expression in oral squamous cell carcinoma (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Di Domenico, Marina Di I; Pierantoni, Giovanna Maria; Feola, Antonia; Esposito, Francesco; Laino, Luigi; De Rosa, Alfredo; Rullo, Rosario; Mazzotta, M.; Martano, Manuela; Sanguedolce, Francesca; Perillo, L.; D'Angelo, Luigi; Papagerakis, Silvana M.; Tortorella, Simona; Bufo, Pantaleo; Lo Muzio, Lorenzo Lo O; Pannone, Giuseppe; Santoro, Angela Scorca (2011)
    Prognostic significance of N-cadherin expression in oral squamous cell carcinoma
    in Anticancer research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Di Domenico, Marina Di I; Pierantoni, Giovanna Maria; Feola, Antonia; Esposito, Francesco; Laino, Luigi; De Rosa, Alfredo; Rullo, Rosario; Mazzotta, M.; Martano, Manuela; Sanguedolce, Francesca; Perillo, L.; D'Angelo, Luigi; Papagerakis, Silvana M.; Tortorella, Simona; Bufo, Pantaleo; Lo Muzio, Lorenzo Lo O; Pannone, Giuseppe; Santoro, Angela Scorca (literal)
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  • 4211 (literal)
Pagina fine
  • 4218 (literal)
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  • http://www.scopus.com/record/display.url?eid=2-s2.0-84855185108&origin=inward (literal)
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  • 31 (literal)
Rivista
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  • 12 (literal)
Note
  • Scopu (literal)
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  • Seconda Universita degli Studi di Napoli; Universita degli Studi di Napoli Federico II; Universita degli Studi di Foggia; University Michigan Ann Arbor; Universita degli Studi di Bari (literal)
Titolo
  • Prognostic significance of N-cadherin expression in oral squamous cell carcinoma (literal)
Abstract
  • Background: N-Cadherin (CDH2) is a calcium-dependent adhesion protein, whose de novo expression, reexpression, up-regulation and down-regulation in human tumors has been demonstrated. The aim of the present work was to define the prognostic role of N-Cadherin in a large series of oral squamous cell carcinomas (OSCCs). Materials and Methods: A total of 94 selected OSCCs were quantitatively and qualitatively analyzed by immunohistochemistry for N-Cadherin. The association between protein expression and clinico-pathological parameters was assessed by statistical analysis. Results: In neoplastic tissue, N-Cadherin levels were more evident than in normal peritumoral epithelium (p<0.05). Protein staining was mainly detected in the neoplastic cells, and only focal nuclear positivity was observed. Expression of cytoplasmic N-Cadherin correlated significantly with poor histological differentiation (p<0.05). Furthermore, we have observed significant a statistical trend for stage and a correlation with worst patient outcome, also confirmed by Kaplan-Meier estimates. Conclusion: Our work has underlined the key-role of N-Cadherin in oral carcinogenesis and in the prognostic stratification of patients. (literal)
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