Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes (Articolo in rivista)

Type
Label
  • Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes (Articolo in rivista) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/la5038074 (literal)
Alternative label
  • Giuliani, Chiara; Atieri, Barbara; Bombelli, Cecilia; Galantini, Luciano; Mancini, Giovanna; Stringaro, Annarita (2015)
    Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes
    in Langmuir; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giuliani, Chiara; Atieri, Barbara; Bombelli, Cecilia; Galantini, Luciano; Mancini, Giovanna; Stringaro, Annarita (literal)
Pagina inizio
  • 76 (literal)
Pagina fine
  • 82 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.pubs.acs.org/Langmuir (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Roma La Sapienza; Univ Roma La Sapienza; Univ Aquila; CNR IMC Ist Metodol Chim; Ist Super Sanita (literal)
Titolo
  • Remote Loading of Aloe Emodin in Gemini-Based Cationic Liposomes (literal)
Abstract
  • Anthraquinone compound aloe-emodin (AE) has shown antineoplastic, antibacterial, antiviral, and anti-inflammatory properties and scavenging activity on free radicals. Because of these therapeutic features, AE has been attracting increasing interest and could be applied in the curing of many diseases. However, until now the physicochemical features of this compound have not been fully investigated; furthermore, its wide application might be hindered by its scarce solubility in aqueous media (similar to 19 mu M). The inclusion of AE in nanocarriers, such as cationic liposomes, could allow its delivery effectively and selectively to target sites, reducing side effects in the remaining tissues. In this work, the weak acid nature of AE, because of its two phenolic functions, was exploited to load it remotely in the internal aqueous phase of liposomes in response to a difference in pH between the inside and outside of the liposomes, pH(in) > pH(out). The inclusion of AE in gemini-based cationic liposomes by the acetate gradient method was obtained at high AE/lipid ratios (up to 1:30). (literal)
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