New insight into clinical development of nucleic acid aptamers. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• New insight into clinical development of nucleic acid aptamers. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Esposito, Carla Lucia; Catuogno, Silvia; De Franciscis, Vittorio; Cerchia, Laura (2011)
  New insight into clinical development of nucleic acid aptamers.
  in Discovery medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Esposito, Carla Lucia; Catuogno, Silvia; De Franciscis, Vittorio; Cerchia, Laura (literal)

Pagina inizio

• 487 (literal)

Pagina fine

• 496 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-80054825739&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Discovery medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 61 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche (literal)

Titolo

• New insight into clinical development of nucleic acid aptamers. (literal)

Abstract

• Nucleic acid-based aptamers have been shown as high-affinity ligands and potential antagonists of disease-associated proteins. Aptamers, isolated from combinatorial libraries by an iterative in vitro selection process, discriminate between closely related targets and are characterized by high specificity and low toxicity thus representing a valid alternative to antibodies to target specific proteins of biomedical interest. Moreover, they are non-immunogenic and can be easily stabilized by chemical modifications thus expanding their therapeutic potential. Here, we will focus on the structural and functional features of aptamers that have entered the clinical development pipeline together with those aptamers holding great potential as therapeutics in preclinical studies. The future perspectives of aptamers as therapeutics will be discussed as well. (literal)

Prodotto di

• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• SILVIA CATUOGNO (Persona)
• LAURA CERCHIA (Persona)
• VITTORIO DE FRANCISCIS (Persona)
• CARLA LUCIA ESPOSITO (Persona)

Incoming links:

Autore CNR di

• LAURA CERCHIA (Persona)
• VITTORIO DE FRANCISCIS (Persona)
• CARLA LUCIA ESPOSITO (Persona)
• SILVIA CATUOGNO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Discovery medicine (Rivista)