Effects of titanium dioxide nanoparticles on sea urchin immune defence. (Abstract/Comunicazione in atti di convegno)

Type

• Prodotto della ricerca (Classe)
• Abstract/Comunicazione in atti di convegno (Classe)

Label

• Effects of titanium dioxide nanoparticles on sea urchin immune defence. (Abstract/Comunicazione in atti di convegno) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Alternative label

• A. Pinsino, Russo, R. Bonaventura, V. Matranga (2014)
  Effects of titanium dioxide nanoparticles on sea urchin immune defence.
  in 2nd Marine NanoEcoSafety Workshop (MANET), BIMAT 2014, Palermo, 17-20 November 2014
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. Pinsino, Russo, R. Bonaventura, V. Matranga (literal)

Pagina inizio

• 30 (literal)

Pagina fine

• 30 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://bimat2014.azuleon.org/_docs/Book_MANET_2014.pdf (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume

• 2nd Marine NanoEcoSafety Workshop (MANET), BIMAT 2014 (literal)

Note

• Comunicazione (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biomedicina e Immunologia Molecolare \"A. Monroy\", CNR, Palermo (literal)

Titolo

• Effects of titanium dioxide nanoparticles on sea urchin immune defence. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn

• 9788890580574 (literal)

Abstract

• The presence of Engineered Nanoparticles and their aggregates in many consumer products has attracted a growing scientific concern on the possible effects of these materials on the environment and biota. Here, we took advantage of an amenable laboratory model organism, the sea urchin Paracentrotus lividus(phylum Echinodermata), to elucidate a potential pathway that can be involved in the persistent Titanium dioxide ( TiO 2 ) engineered nanoparticles-immune cell interaction. Sea urchins are phylogenetically related to humans (at least 70% of their proteins are shared with humankind), and have been proven to possess a complex and effective immune defence. In this study, TiO 2 nanoparticles were injected into the sea urchins body cavity to expose immune cells, that were harvested after 24 hours, and analyzed for their morphology, phagocytic ability, activation of proteins triggering immune defence (e.g. HSPs, TLRs, p38 MAPK) and expression of related immune response genes. We found that TiO 2 nanoparticles elicit a receptor-mediated endocytotic mechanism carried out by phagocytes, and affect the p38 MAPK signaling pathway. Our working hypothesis is based on the role of the TiO2 nanoparticles-mediated p38 MAPK inactivation in the renewal and homeostasis of sea urchin immune \"stem\" cells. In conclusion, we strongly recommend sea urchin immune cells as a new powerful tool for nanosafety investigations. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Stress Cellulare ed Ambiente (SV.P17.008.003) (Modulo)

Autore CNR

• VALERIA MATRANGA (Unità di personale interno)
• ANNALISA PINSINO (Persona)
• ROBERTA RUSSO (Persona)
• ROSA BONAVENTURA (Unità di personale interno)

Incoming links:

Autore CNR di

• VALERIA MATRANGA (Unità di personale interno)
• ROSA BONAVENTURA (Unità di personale interno)
• ANNALISA PINSINO (Persona)
• ROBERTA RUSSO (Persona)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Stress Cellulare ed Ambiente (SV.P17.008.003) (Modulo)