Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2459/JCM.0000000000000068 (literal)

Alternative label

• Andrea Borghini, Silverio Sbrana, Cecilia Vecoli, Antonella Mercuri, Stefano Turchi, Clara Carpeggiani, Antonio L'Abbate and Maria G. Andreassi (2014)
  Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance
  in Journal of cardiovascular medicine (Hagerstown, Md. : Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andrea Borghini, Silverio Sbrana, Cecilia Vecoli, Antonella Mercuri, Stefano Turchi, Clara Carpeggiani, Antonio L'Abbate and Maria G. Andreassi (literal)

Pagina inizio

• 710 (literal)

Pagina fine

• 716 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Journal of cardiovascular medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• PubMed (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Clinical Physiology, CNR, via Moruzzi 1, 56124 Pisa, Italy (literal)

Titolo

• Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance (literal)

Abstract

• Aim: Genome-wide association studies have identified single-nucleotide polymorphisms at the 10q11 locus as risk factors for myocardial infarction (MI). This locus lies upstream (?80 kb) of the stromal cell-derived factor-1 (SDF1) gene that codes for a chemokine with protective atherogenetic effects and with a major role in the mobilization, homing, and differentiation of endothelial progenitor cells (EPCs). The purpose of this study was to investigate the possible association of SDF1-3'A polymorphism, that upregulates SDF1 protein expression, with MI as well as early endothelial dysfunction and atherosclerosis in young healthy subjects. Methods: 200 patients (181 men age 57.3+/-7.7 years) and 230 healthy controls (96 men, age 52+/-11.9 years) were recruited to investigate the association between MI and SDF1-30A polymorphism. The relationship between SDF1-3'A polymorphism, brachial artery flow-mediated dilation, and the number of circulating EPCs was examined in 50 healthy young adults. Results: A significant difference in SDF1-3'A genotype distribution was observed between patients and controls (P=0.006). Patients carrying the A allele had a significantly reduced MI risk compared with subjects with GG genotype (odds ratio=0.5, 95% CI=0.3-0.9, P=0.001). SDF1-3'A polymorphism presented a significant interaction with other cardiovascular risk factors (Pinteraction<0. 0001). Controls carrying the A allele showed significantly higher flow-mediated dilation (13.9+/-4.9 vs 10.8+/-4.3, P=0.03) and significantly higher values of EPCs (0.029+/-0.009 vs 0.022+/-0.008, P=0.02) compared with GG homozygotes. Conclusion: SDF1-3'A polymorphism is associated with a decreased risk of MI and early endothelial dysfunction, strongly confirming the important atherogenic role of the SDF1 gene at the clinical level. (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• ANTONELLA MERCURI (Unità di personale interno)
• ANTONIO L'ABBATE (Persona)
• MARIAGRAZIA ANDREASSI (Unità di personale interno)
• SILVERIO SBRANA (Unità di personale interno)
• CLARA CARPEGGIANI (Persona)
• CECILIA VECOLI (Unità di personale interno)
• STEFANO TURCHI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIAGRAZIA ANDREASSI (Unità di personale interno)
• ANTONIO L'ABBATE (Persona)
• ANTONELLA MERCURI (Unità di personale interno)
• CLARA CARPEGGIANI (Persona)
• STEFANO TURCHI (Unità di personale interno)
• CECILIA VECOLI (Unità di personale interno)
• SILVERIO SBRANA (Unità di personale interno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cardiovascular medicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "Stromal cell-derived factor-1-30A polymorphism is associated with decreased risk of myocardial infarction and early endothelial disturbance" (Insieme di parole chiave)