Controlled Release of Tramadol from Mixed Matrix Membranes (Articolo in rivista)

Type
Label
  • Controlled Release of Tramadol from Mixed Matrix Membranes (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.6000/1929-6037.2012.01.02.8 (literal)
Alternative label
  • L. Donato, G. Barbaro, E. Drioli, C. Algieri (2012)
    Controlled Release of Tramadol from Mixed Matrix Membranes
    in Journal of Membrane and Separation Technology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Donato, G. Barbaro, E. Drioli, C. Algieri (literal)
Pagina inizio
  • 137 (literal)
Pagina fine
  • 144 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.lifescienceglobal.com/home/cart?view=product&id=319 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • ITM - Istituto per la tecnologia delle membrane (literal)
Titolo
  • Controlled Release of Tramadol from Mixed Matrix Membranes (literal)
Abstract
  • In this work mixed matrix membranes (zeolite loaded) were prepared and tested as potential devices for the controlled release of tramadol hydrochloride. Due to the hydrophilic nature of the drug, a hydrophobic polymer (polydimethylsiloxane) was chosen for the membrane preparation. NaX zeolites was added to PDMS matrix as modulating agent with the aim to obtain a linear and adequate delivery of the drug in the time as required by the therapeutic needs of this opioid. About the different investigated systems, the PDMS membrane containing 17 wt% of zeolite and 0.2 wt% of drug seems to be the most promising for application as transdermal device. Different mathematical models (Zero order, First order, Higuchi, Bhaskar, and Korsemeyer-Peppas) were used to interpret the drug release mechanism from the different Mixed matrix membranes. The experimental data showed good fit with three different models: Higuchi, Bhaskar and Korsemeyer-Peppas. (literal)
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