Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Alternative label

• Esposito, Davide; Crescenzi, Elvira; Sagar, Vinay; Loreni, Fabrizio; Russo, Annapina; Russo, Giulia (2014)
  Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.
  in Oncotarget
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Esposito, Davide; Crescenzi, Elvira; Sagar, Vinay; Loreni, Fabrizio; Russo, Annapina; Russo, Giulia (literal)

Pagina inizio

• 11737 (literal)

Pagina fine

• 51 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84917690899&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Oncotarget (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 22 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Molecular Medicine and Medical Biotechnology, University of Naples \"Federico II\", Naples 80131, Italy. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (literal)

Titolo

• Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP. (literal)

Abstract

• Recent evidence showed that a variety of DNA damaging agents including 5-FU and L-OHP impairs ribosomal biogenesis activating a ribosomal stress pathway. Here, we demonstrate that in lung and colon cancer cell lines devoid of p53, the efficacy of 5-FU and L-OHP chemotherapy depends on rpL3 status. Specifically, we demonstrate that ribosomal stress induced by 5-FU and L-OHP is associated to up-regulation of rpL3 and its accumulation as ribosome-free form. We show that rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle, apoptosis and DNA repair, by modulating p21 expression. Moreover, we demonstrate that rpL3 is able to control DNA repair also independently from p21 status of cell. It is noteworthy that silencing of rpL3 abolishes the cytotoxic effects of 5-FU and L-OH indicating that the loss of rpL3 makes chemotherapy drugs ineffective. Taking together our results shed light on 5-FU and L-OHP mechanism of action and contribute to more effective clinical use of these drugs in cancer therapy. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Identificazione e caratterizzazione funzionale dei geni e delle proteine coinvolti nella tumorigenesi tiroidea (SV.P15.001.004) (Modulo)

Autore CNR

• ELVIRA CRESCENZI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ELVIRA CRESCENZI (Unità di personale interno)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Identificazione e caratterizzazione funzionale dei geni e delle proteine coinvolti nella tumorigenesi tiroidea (SV.P15.001.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Oncotarget (Rivista)

Insieme di parole chiave di

• Parole chiave di "Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP." (Insieme di parole chiave)