An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000093604 (literal)

Alternative label

• Boncoraglio G.B.; Bodini A.; Brambilla C.; Carriero M.R.; Ciusani E.; Parati E.A. (2006)
  An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke
  in Cerebrovascular diseases (Basel); Karger, Basel (Swaziland)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Boncoraglio G.B.; Bodini A.; Brambilla C.; Carriero M.R.; Ciusani E.; Parati E.A. (literal)

Pagina inizio

• 191 (literal)

Pagina fine

• 195 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Cerebrovascular diseases (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto Nazionale Neurologico C. Besta, Milano; IMATI-CNR, Milano; IMATI-CNR, Milano; Istituto Nazionale Neurologico C. Besta, Milano; Istituto Nazionale Neurologico C. Besta, Milano; Istituto Nazionale Neurologico C. Besta, Milano (literal)

Titolo

• An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke (literal)

Abstract

• Background and Purpose: The gene-encoding plasminogen activator inhibitor type 1 (PAI-1) has a common 4G/5G 'functional' polymorphism, and people homozygous for the4G allele have higher PAI-1 plasma concentrations. The 4G/4G genotype is associated with increased risk of myocardial infarction but paradoxically protects against stroke. We hypothesized that this paradox may be explained via an effect of the PAI-1 polymorphism on plasma lipids. Methods: We studied 71 consecutive Italian patients referred to our Institute for first stroke or vascular cognitive impairment. PAI-1 gene 4G/5G polymorphism, total plasma cholesterol, plasma triglycerides, sex, age, smoking, oral contraceptive use, statin therapy, hypertension, diabetes, and history of myocardial infarction were examined. Results: The 4G/4G genotype was significantly associated with high cholesterol (p = 0.003) but not with triglycerides (p = 0.39). Adjusted odds ratios were: 5.8 for 4G/4G vs. 4G/5G (95% CI, 3.1-23.0), and 15.9 for 4G/4G vs. 5G/5G (95% CI, 2.4-105.0). Conclusions: This finding may explain the involvement of the PAI- polymorphism in the clustering of atherothrombotic risk factors, and why people with the 4G/4G genotype are at increased risk for myocardial infarction. Stroke is not so clearlyrelated to hypercholesterolemia and other effects of the 4G/4G genotype (perhaps increased PAI-1 expression) may protect against stroke. (literal)

Editore

• Karger (Editore)

Prodotto di

• Istituto di matematica applicata e tecnologie informatiche \"Enrico Magenes\" (IMATI) (Istituto)
• Metodi statistici per problemi biomedici (ME.P07.004.002) (Modulo)

Autore CNR

• ANTONELLA BODINI (Persona)
• CARLA BRAMBILLA (Persona)

Insieme di parole chiave

• Keywords of "An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CARLA BRAMBILLA (Persona)
• ANTONELLA BODINI (Persona)

Prodotto

• Istituto di matematica applicata e tecnologie informatiche \"Enrico Magenes\" (IMATI) (Istituto)
• Metodi statistici per problemi biomedici (ME.P07.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cerebrovascular diseases (Rivista)

Editore di

• Karger (Editore)

Insieme di parole chiave di

• Keywords of "An effect of PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke" (Insieme di parole chiave)