Microstructured polydimethylsiloxane membranes for peripheral nerve regeneration (Articolo in rivista)

Type
Label
  • Microstructured polydimethylsiloxane membranes for peripheral nerve regeneration (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.mee.2014.04.014 (literal)
Alternative label
  • Jacchetti E.; Tonazzini I.; Meucci S.; Beltram F.; Cecchini M. (2014)
    Microstructured polydimethylsiloxane membranes for peripheral nerve regeneration
    in Microelectronic engineering
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Jacchetti E.; Tonazzini I.; Meucci S.; Beltram F.; Cecchini M. (literal)
Pagina inizio
  • 26 (literal)
Pagina fine
  • 29 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84899795957&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 124 (literal)
Rivista
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • NEST, Scuola Normale Superiore, Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127 Pisa, Italy; Center for Nanotechnology Innovation NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy (literal)
Titolo
  • Microstructured polydimethylsiloxane membranes for peripheral nerve regeneration (literal)
Abstract
  • We engineered anisotropic microstructured membranes for nerve repair applications by exploiting electron beam lithography on silicon substrates and soft lithography techniques. Our substrates were patterned with polydimethylsiloxane (PDMS) gratings (alternating lines of grooves and ridges) of varying ridge/groove width and depth. These gratings were used as scaffolds to study rat Schwann cell contact interaction for cell migration. We observed that cell motion was affected by the presence of the grating and by its periodicity, while cells on flat substrates showed random spatial migration. Our results allow the identification of specific topographical elements that may be exploited for the production of new devices for enhancing nerve regeneration by promoting Schwann cell invasion, proliferation, and terminal differentiation. © 2014 Elsevier B.V. All rights reserved. (literal)
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