http://www.cnr.it/ontology/cnr/individuo/prodotto/ID311061

Tubeless biochip for tailoring cell co-cultures in closed microchambers (Articolo in rivista)

Type

Label

Tubeless biochip for tailoring cell co-cultures in closed microchambers (Articolo in rivista) (literal)

Anno

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Alternative label

Meucci S.[ 1,2,3 ]; Vittorio O.[ 1,2,3 ]; Beltram F.[ 1,2,3 ]; Cecchini M. [1,2 ] (2014)
Tubeless biochip for tailoring cell co-cultures in closed microchambers
in Microelectronic engineering
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Meucci S.[ 1,2,3 ]; Vittorio O.[ 1,2,3 ]; Beltram F.[ 1,2,3 ]; Cecchini M. [1,2 ] (literal)

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Rivista

Note

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[ 1 ] Scuola Normale Super Pisa, NEST, I-56127 Pisa, Italy [ 2 ] CNR, Ist Nanosci, I-56127 Pisa, Italy [ 3 ] Ist Italian Tecnol, Ctr Nanotechnol Innovat NEST, I-56127 Pisa, Italy (literal)

Titolo

Tubeless biochip for tailoring cell co-cultures in closed microchambers (literal)

Abstract

Lab-on-a-Chip devices exploit micro/nanoengineering techniques to develop miniaturized systems for handling and manipulating small volumes of fluids. Here, we demonstrate a microfluidic device for culturing cells in closed microchambers that is designed to be compatible with standard biological procedures. This approach facilitates the thermal and gaseous equilibration of all the components, preventing the nucleation of air bubbles. Serial asymmetrical loadings were performed to realize co-cultures with initial topographical organization. The migration of two different cell types was monitored for 72 h by high-resolution fluorescence imaging. © 2014 Elsevier B.V. All rights reserved. (literal)

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