Improvement of the healing process in superficial skin wounds after treatment with EMOLED (Contributo in atti di convegno)

Type
Label
  • Improvement of the healing process in superficial skin wounds after treatment with EMOLED (Contributo in atti di convegno) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1117/12.2052188 (literal)
Alternative label
  • Cicchi R.; Rossi F.; Tatini F.; Bacci S.; De Siena G.; Alfieri D.; Pini R.; Pavone F.S. (2014)
    Improvement of the healing process in superficial skin wounds after treatment with EMOLED
    in Conference on Biophotonics - Photonic Solutions for Better Health Care IV, Brussels, BELGIUM, APR 14-17, 2014
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cicchi R.; Rossi F.; Tatini F.; Bacci S.; De Siena G.; Alfieri D.; Pini R.; Pavone F.S. (literal)
Pagina inizio
  • 91293X (literal)
Pagina fine
  • 91293X (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84903766347&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Photonic Solutions for Better Health Care IV (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9129 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
  • 9129 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • National Institute of Optics, National Research Council, Largo E. Fermi 6, I-50125, Florence, Italy; European Laboratory for Non-linear Spectroscopy (LENS), Via Nello Carrara 1, I-50019, Sesto Fiorentino, Italy; Institute of Applied Physics Nello Carrara, National Research Council, Via Madonna del Piano 10, I-50019, Sesto Fiorentino, Italy; Department of Human Anatomy, Histology, and Legal Medicine, Section of Histology, University of Florence, Viale Pieraccini 6, I-50139, Florence, Italy; Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, I-50139, Florence, Italy; Light4Tech Firenze S.r.L., Via Pisana 316, I-50018 Scandicci (FI), Italy; Department of Physics, University of Florence, Via Giovanni Sansone 1, I-50019, Sesto Fiorentino, Italy (literal)
Titolo
  • Improvement of the healing process in superficial skin wounds after treatment with EMOLED (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-1-62841-077-8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Popp, J; Tuchin, VV; Matthews, DL; Pavone, FS (literal)
Abstract
  • A faster healing process was observed in superficial skin wounds after irradiation with the EMOLED photocoagulator. The instrument consists of a compact handheld photocoagulation device, useful for inducing coagulation in superficial abrasions. The illumination is provided by a high power blue LED. Blue light is selectively absorbed by haemoglobin and converted into heat through a photothermal effect. In this study, 10 Sprague Dawley rats were mechanically abraded in four regions of their back: two regions were used as a control and the other two were treated with EMOLED. The photothermal effect was monitored by an infrared thermocamera in order to avoid accidental thermal damage. Visual observations, histopathological analysis and non-linear microscopic imaging performed after 8 days from the treatment showed no adverse reactions and no thermal damage in both treated areas and surrounding tissues. Moreover, a faster healing process and a better-recovered morphology was evidenced in the treated tissue with respect to the untreated tissue. Compared to the control regions, a reduced inflammatory response, a higher collagen content, and a skin morphology more similar to normal skin were observed in the treated regions. Collagen organization in the two regions was characterized using image pattern analysis algorithms on SHG images, demonstrating a fully recovered aspect of dermis as well as a faster neocollagenesis in the treated regions. This study demonstrates that the selective photothermal effect we used for inducing immediate coagulation in superficial wounds is associated to a minimal inflammatory response, which provides reduced recovery times and improved healing process. © 2014 SPIE. (literal)
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