http://www.cnr.it/ontology/cnr/individuo/prodotto/ID309162
Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients (Articolo in rivista)
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- Label
- Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.dld.2011.10.022 (literal)
- Alternative label
Arciello, Mario; Petta, Salvatore; Leoni, Valerio; Iannucci, Gino; Labbadia, Giancarlo; Cammà, Carlo; Craxì, Antonio; Balsano, Clara (2012)
Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients
in Digestive and Liver Disease
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Arciello, Mario; Petta, Salvatore; Leoni, Valerio; Iannucci, Gino; Labbadia, Giancarlo; Cammà, Carlo; Craxì, Antonio; Balsano, Clara (literal)
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- ISI Web of Science (WOS) (literal)
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- Universita degli Studi dell'Aquila; Laboratory of Molecular Virology and Oncology; Universita degli Studi di Palermo; Istituto Nazionale Neurologico C Besta, Milan; Universita degli Studi di Roma La Sapienza (literal)
- Titolo
- Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients (literal)
- Abstract
- Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-?-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism. Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-?-hydroxycholesterol were determined by isotope dilution gas chromatography/mass spectrometry. Results: Gas chromatography/mass spectrometry revealed higher 7-ketocholesterol (71.2 ± 77.3 vs 30.4 ± 14.5; p<0.005) and 7-?-hydroxycholesterol (23.7 ± 20.6 vs 11.5 ± 4.9; p<0.001) plasma levels in hepatitis C virus patients. Furthermore, multivariate regression analysis highlighted an inverse independent correlation between high oxysterol levels and low low-density lipoprotein cholesterol (p=0.01 for 7-?-hydroxycholesterol; p=0.02 for 7-ketocholesterol) in the hepatitis C virus group; in contrast, the non-alcoholic fatty liver disease group showed a direct correlation between oxysterol levels and low-density lipoprotein-cholesterol (p<0.001 for 7-?-hydroxycholesterol; p=0.002 for 7-ketocholesterol). Conclusion: These different correlations reveal profound differences in lipid dysmetabolism between chronic hepatitis C and non-alcoholic fatty liver disease patients. © 2011 Editrice Gastroenterologica Italiana S.r.l. (literal)
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