http://www.cnr.it/ontology/cnr/individuo/prodotto/ID307922
A census of RND superfamily proteins in the Burkholderia genus (Articolo in rivista)
- Type
- Label
- A census of RND superfamily proteins in the Burkholderia genus (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2217/fmb.13.50 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Perrin E.; Fondi M.; Papaleo M.C.; Maida I.; Emiliani G.; Buroni S.; Pasca M.R.; Riccardi G.; Fani R. (literal)
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84880104229&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratory of Molecular and Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy; Computer Laboratory, University of Cambridge, Cambridge, United Kingdom; Trees and Timber Institute, National Research Council, via Madonna del Piano, 10, 50019 Florence, Italy; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy; Laboratory of Molecular and Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy (literal)
- Titolo
- A census of RND superfamily proteins in the Burkholderia genus (literal)
- Abstract
- Aim: The aim of this work was to analyze the eight resistance-nodulation- cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These 'core' proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined. © 2013 Future Medicine Ltd. (literal)
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