A census of RND superfamily proteins in the Burkholderia genus (Articolo in rivista)

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Label
  • A census of RND superfamily proteins in the Burkholderia genus (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2217/fmb.13.50 (literal)
Alternative label
  • Perrin E.; Fondi M.; Papaleo M.C.; Maida I.; Emiliani G.; Buroni S.; Pasca M.R.; Riccardi G.; Fani R. (2013)
    A census of RND superfamily proteins in the Burkholderia genus
    in Future microbiology (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Perrin E.; Fondi M.; Papaleo M.C.; Maida I.; Emiliani G.; Buroni S.; Pasca M.R.; Riccardi G.; Fani R. (literal)
Pagina inizio
  • 923 (literal)
Pagina fine
  • 937 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84880104229&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 8 (literal)
Rivista
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  • 7 (literal)
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  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laboratory of Molecular and Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy; Computer Laboratory, University of Cambridge, Cambridge, United Kingdom; Trees and Timber Institute, National Research Council, via Madonna del Piano, 10, 50019 Florence, Italy; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Via Ferrata 9, 27100 Pavia, Italy; Laboratory of Molecular and Microbial Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Fi), Italy (literal)
Titolo
  • A census of RND superfamily proteins in the Burkholderia genus (literal)
Abstract
  • Aim: The aim of this work was to analyze the eight resistance-nodulation- cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These 'core' proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined. © 2013 Future Medicine Ltd. (literal)
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