http://www.cnr.it/ontology/cnr/individuo/prodotto/ID307504

Fusion of HCV non-structural antigen to MHC Class II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human primates. (Articolo in rivista)

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Fusion of HCV non-structural antigen to MHC Class II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human primates. (Articolo in rivista) (literal)

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Stefania Capone 1, Mariarosaria Naddeo 1, Anna Morena D'Alise 1, Adele Abbate 1, Fabiana Grazioli 1, Annunziata Del Gaudio 1, Mariarosaria del Sorbo 1, Maria Luisa Esposito 1, Virginia Ammendola 1, Gemma Perretta 2, Alessandra Taglioni 2, Stefano Colloca 1, Alfredo Nicosia 1,3,4, Riccardo Cortese 1,5 and Antonella Folgori 1 (2014)
Fusion of HCV non-structural antigen to MHC Class II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human primates.
in Molecular therapy (Print); Nature Publishing Group, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Stefania Capone 1, Mariarosaria Naddeo 1, Anna Morena D'Alise 1, Adele Abbate 1, Fabiana Grazioli 1, Annunziata Del Gaudio 1, Mariarosaria del Sorbo 1, Maria Luisa Esposito 1, Virginia Ammendola 1, Gemma Perretta 2, Alessandra Taglioni 2, Stefano Colloca 1, Alfredo Nicosia 1,3,4, Riccardo Cortese 1,5 and Antonella Folgori 1 (literal)

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1 Okairos, Rome, Italy; 2 Cellular Biology and Neurobiology Institute (IBCN) National Research Council of Italy, Rome, Italy; 3 CEINGE, Naples, Italy; 4 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy; 5 Okairos AG, c/o OBC Suisse AG, Basel, Switzerland (literal)

Titolo

Fusion of HCV non-structural antigen to MHC Class II associated invariant chain enhances T cell responses induced by vectored vaccines in non-human primates. (literal)

Abstract

Despite viral vectors being potent inducers of antigen-specific T cells, strategies to further improve their immunogenicity are actively pursued. Of the numerous approaches investigated, fusion of the encoded antigen to major histocompatibility complex class II-associated invariant chain (Ii) has been reported to enhance CD8+ T-cell responses. We have previously shown that adenovirus vaccine encoding nonstructural (NS) hepatitis C virus (HCV) proteins induces potent T-cell responses in humans. However, even higher T-cell responses might be required to achieve efficacy against different HCV genotypes or therapeutic effect in chronically infected HCV patients. In this study, we assessed fusion of the HCV NS antigen to murine and human Ii expressed by the chimpanzee adenovirus vector ChAd3 or recombinant modified vaccinia Ankara in mice and nonhuman primates (NHPs). A dramatic increase was observed in outbred mice in which vaccination with ChAd3 expressing the fusion antigen resulted in a 10-fold increase in interferon-?+ CD8+ T cells. In NHPs, CD8+ T-cell responses were enhanced and accelerated with vectors encoding the Ii-fused antigen. These data show for the first time that the enhancement induced by vector vaccines encoding li-fused antigen was not species specific and can be translated from mice to NHPs, opening the way for testing in humans. (literal)

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