A novel description of FDG excretion in the renal system: application to metformin-treated models (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A novel description of FDG excretion in the renal system: application to metformin-treated models (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1088/0031-9155/59/10/2469 (literal)

Alternative label

• Garbarino, S.; Caviglia, G.; Sambuceti, G.; Benvenuto, F.; Piana, M. (2014)
  A novel description of FDG excretion in the renal system: application to metformin-treated models
  in Physics in medicine and biology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Garbarino, S.; Caviglia, G.; Sambuceti, G.; Benvenuto, F.; Piana, M. (literal)

Pagina inizio

• 2469 (literal)

Pagina fine

• 2484 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 59 (literal)

Rivista

• Physics in medicine and biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 16 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Genoa; CNR SPIN Genova; University of Genoa; University of Genoa; Ecole Polytechnique (literal)

Titolo

• A novel description of FDG excretion in the renal system: application to metformin-treated models (literal)

Abstract

• This paper introduces a novel compartmental model describing the excretion of 18F-fluoro-deoxyglucose (FDG) in the renal system and a numerical method based on the maximum likelihood for its reduction. This approach accounts for variations in FDG concentration due to water re-absorption in renal tubules and the increase of the bladder's volume during the FDG excretion process. From the computational viewpoint, the reconstruction of the tracer kinetic parameters is obtained by solving the maximum likelihood problem iteratively, using a non-stationary, steepest descent approach that explicitly accounts for the Poisson nature of nuclear medicine data. The reliability of the method is validated against two sets of synthetic data realized according to realistic conditions. Finally we applied this model to describe FDG excretion in the case of animal models treated with metformin. In particular we show that our approach allows the quantitative estimation of the reduction of FDGde-phosphorylation induced by metformin. (literal)

Prodotto di

• Analisi e modellizzazione di nanodispositivi quantistici e di sistemi complessi (MD.P02.023.002) (Modulo)
• Superconduttività: materiali, meccanismi e trasferimento tecnologico (MD.P04.023.001) (Modulo)

Autore CNR

• MICHELE PIANA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "A novel description of FDG excretion in the renal system: application to metformin-treated models" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MICHELE PIANA (Unità di personale esterno)
• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID23280

Prodotto

• Analisi e modellizzazione di nanodispositivi quantistici e di sistemi complessi (MD.P02.023.002) (Modulo)
• Superconduttività: materiali, meccanismi e trasferimento tecnologico (MD.P04.023.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Physics in medicine and biology (Rivista)

Insieme di parole chiave di

• Keywords of "A novel description of FDG excretion in the renal system: application to metformin-treated models" (Insieme di parole chiave)