http://www.cnr.it/ontology/cnr/individuo/prodotto/ID307
Hierarchical mechanochemical switches in angiostatin (Articolo in rivista)
- Type
- Label
- Hierarchical mechanochemical switches in angiostatin (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
Grandi, F; Sandal, M; Guarguaglini, G; Capriotti, E; Casadio, R; Samori, B (2006)
Hierarchical mechanochemical switches in angiostatin
in ChemBioChem (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Grandi, F; Sandal, M; Guarguaglini, G; Capriotti, E; Casadio, R; Samori, B (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Univ Bologna, Dept Biochem, I-40126 Bologna, Italy; INFM, Natl Ctr Nanostruct & Biosyst, Surfaces S3, I-41100 Modena, Italy; Univ Bologna, Dept Biol, CIRB Lab Biocomp, I-40126 Bologna, Italy (literal)
- Titolo
- Hierarchical mechanochemical switches in angiostatin (literal)
- Abstract
- We wish to propose a novel mechanism by which the triggering of a biochemical signal can be controlled by the hierarchical coupling between a protein redox equilibrium and an external mechanical force. We have characterized this mechanochemical mechanism in angiostatin, and we have evidence that it can switch the access to partially unfolded structures of this protein. We have identified a metastable intermediate that is specifically accessible under thioredoxin-rich reducing conditions, like those met by angiostatin on the surface of a tumor cell. The structure of the same intermediate accounts for the unexplained antiangiogenic activity of angiostatin. These findings demonstrate a new link between redox biology and mechanically regulated processes. (literal)
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