A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nmd.2014.11.006 (literal)

Alternative label

• Esposito T*, Sampaolo S, Gianfrancesco F, Napolitano F, Lombardi L, Lucà R, Roperto F, and Di Iorio G (2015)
  A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease
  in Neuromuscular disorders
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Esposito T*, Sampaolo S, Gianfrancesco F, Napolitano F, Lombardi L, Lucà R, Roperto F, and Di Iorio G (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Esposito Teresa corresponding author Esposito T e Sampaolo S equal first author (literal)

Rivista

• Neuromuscular disorders (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Neurology Clinic II, Department of Medical Sciences, Surgery, Neurology, Metabolic Diseases and Geriatrics, Second University of Naples, Italy. 2Institute of Genetics and Biophysics \"Adriano Buzzati-Traverso\", National Research Council, Naples, Italy. Electronic address: teresa.esposito@igb.cnr.it. 3Institute of Genetics and Biophysics \"Adriano Buzzati-Traverso\", National Research Council, Naples, Italy. 4Department of Veterinary Medicine and Animal Production, University of Naples \"Federico II\", Italy. (literal)

Titolo

• A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease (literal)

Abstract

• We report the clinical, neuro-imaging, pathological and biochemical features of an Italian family in which two siblings have the Adult Polyglucosan Body Disease (APBD). APBD is a rare autosomal recessive disorder characterized by a gradually progressive involvement of both the central and peripheral nervous systems caused by the deficiency of the glycogen branching enzyme (GBE1). The two affected siblings, a 64-year-old man and his 67-year-old sister who had complained of urinary urgency and sporadic incontinence and also progressive gait difficulty for 6 and 7 years respectively, had severely impaired deep sensations on direct examination and a moderately severe symmetrical, axonal sensory-motor neuropathy on electrophysiological testing. GBE1 activity was below 25% of the normal rate in leukocytes and sural nerves. The siblings were homozygous for the novel GBE1 mutation p.N541D. All other members of the pedigree are heterozygous and manifest no symptoms, even in the very elderly. The affected siblings showed polyglucosan bodies (PBs) included within non-myelinating Schwann cells and within lymphocyte vesicles, which were positive for the autophagy markers P62 and LC3-II at immunofluorescence microscopy. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)

Autore CNR

• TERESA ESPOSITO (Unità di personale interno)
• FERNANDO GIANFRANCESCO (Persona)
• Filomena Napolitano (Persona)

Insieme di parole chiave

• Parole chiave di "A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FERNANDO GIANFRANCESCO (Persona)
• TERESA ESPOSITO (Unità di personale interno)
• Filomena Napolitano (Persona)

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuromuscular disorders (Rivista)

Insieme di parole chiave di

• Parole chiave di "A novel GBE1 mutation and features of polyglucosan bodies autophagy in Adult Polyglucosan Body Disease" (Insieme di parole chiave)