The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.chemphys.2007.08.001 (literal)

Alternative label

• Russo, D (2008)
  The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution
  in Chemical physics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Russo, D (literal)

Pagina inizio

• 200 (literal)

Pagina fine

• 211 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 345 (literal)

Rivista

• Chemical physics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Care of Inst Laue Langevin, CNR, INFM, CRS SOFT, Grenoble, France (literal)

Titolo

• The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution (literal)

Abstract

• Kosmotropic (order-making) and chaotropic (order-breaking) co-solvents influence stability and biochemical equilibrium in aqueous solutions of proteins, acting indirectly through the structure and dynamics of the hydration water that surrounds the protein molecules. We have investigated the influence of kosmotropic and chaotropic co-solvents on the hydrogen bonding network dynamics of both bulk water and hydration water. To this end the evolution of bulk water and hydration water dynamics of a prototypical hydrophobic amino acid with polar backbone, N-acetyl-leucine-methylamide (NALMA), has been studied by quasielastic neutron scattering as a function of solvent composition. The results show that bulk water and hydration water dynamics, apart from a dynamical suppression that depends on the NALMA solute, exhibit the same dependence on addition of co-solvent for all of the co-solvents studied (urea, glycerol, MgSO4, and dimethyl sulfoxide). The hydrophobic solute and the high concentration water-structuring additive have the same effect on the water hydrogen bonding network. Water remains the preferential hydration of the hydrophobic side chain and backbone. We also find that the reorganization of the bulk water hydrogen bond network, upon addition of kosmotrope and chaotrope additives, is not dynamically perturbed, and that the hydrogen bond lifetime is maintained at 1 ps as in pure bulk water. On the other hand the addition of NALMA to the water/co-solvent binary system causes reorganization of the hydrogen bonds, resulting in an increased hydrogen bond lifetime. Furthermore, the solute's side chain dynamics is not affected by high concentrations of co-solvent. We shall discuss the hydration dynamics results in the context of protein folding and protein-solvent interactions. (C) 2007 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Materia soffice: diffusione elastica ed anelastica di neutroni e raggi-x (MD.P02.016.001) (Modulo)

Autore CNR

• DANIELA RUSSO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DANIELA RUSSO (Unità di personale interno)

Prodotto

• Materia soffice: diffusione elastica ed anelastica di neutroni e raggi-x (MD.P02.016.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chemical physics (Rivista)

Insieme di parole chiave di

• Parole chiave di "The impact of kosmotropes and chaotropes on bulk and hydration shell water dynamics in a model peptide solution" (Insieme di parole chiave)