Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.metabol.2011.08.001 (literal)

Alternative label

• Andrea Tura [a], Giovanni Pacini [a], Alexandra Kautzky-Willer [b], Amalia Gastaldelli [c], Ralph A. DeFronzo [d], Ele Ferrannini [c, e], Andrea Mari [a] (2012)
  Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models
  in Metabolism, clinical and experimental (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andrea Tura [a], Giovanni Pacini [a], Alexandra Kautzky-Willer [b], Amalia Gastaldelli [c], Ralph A. DeFronzo [d], Ele Ferrannini [c, e], Andrea Mari [a] (literal)

Pagina inizio

• 434 (literal)

Pagina fine

• 443 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Accepted 16 October 2011. - ID_PUMA: cnr.ifc/2011-A0-133 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21944265 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 61 (literal)

Rivista

• Metabolism, clinical and experimental (Rivista)

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• epub (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [a] Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy; [b] Unit of Gender Medicine, Division of Endocrinology and Metabolism, Clinic of Internal Medicine III, Medical University of Vienna, Austria; [c] Institute of Clinical Physiology, National Research Council, Pisa, Italy; [d] Department of Medicine, Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; [e] Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy (literal)

Titolo

• Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models (literal)

Abstract

• Our aim was to compare traditional C-peptide-based method and insulin-based method with standardized kinetic parameters in the estimation of prehepatic insulin secretion rate (ISR). One-hundred thirty-four subjects with varying degrees of glucose tolerance received an insulin-modified intravenous glucose tolerance test and a standard oral glucose tolerance test with measurement of plasma insulin and C-peptide. From the intravenous glucose tolerance test, we determined insulin kinetics parameters and selected standardized kinetic parameters based on mean values in a selected subgroup. We computed ISR from insulin concentration during the oral glucose tolerance test using these parameters and compared ISR with the standard C-peptide deconvolution approach. We then performed the same comparison in an independent data set (231 subjects). In the first data set, total ISRs from insulin and C-peptide were highly correlated (R(2) = 0.75, P < .0001), although on average different (103 +/- 6 vs 108 +/- 3 nmol, P < .001). Good correlation was also found in the second data set (R(2) = 0.54, P < .0001). The insulin method somewhat overestimated total ISR (85 +/- 5 vs 67 +/- 3 nmol, P = .002), in part because of differences in insulin assay. Similar results were obtained for fasting ISR. Despite the modest bias, the insulin and C-peptide methods were consistent in predicting differences between groups (eg, obese vs nonobese) and relationships with other physiological variables (eg, body mass index, insulin resistance). The insulin method estimated first-phase ISR peak similarly to the C-peptide method and better than the simple use of insulin concentration. The insulin-based ISR method compares favorably with the C-peptide approach. The method will be particularly useful in data sets lacking C-peptide to assess beta-cell function through models requiring prehepatic secretion. (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR

• eleuterio ferrannini (Unità di personale esterno)
• GIOVANNI PACINI (Unità di personale interno)
• ANDREA MARI (Unità di personale interno)
• AMALIA GASTALDELLI (Persona)
• ANDREA TURA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• AMALIA GASTALDELLI (Persona)
• GIOVANNI PACINI (Unità di personale interno)
• ANDREA MARI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)
• eleuterio ferrannini (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Metabolism, clinical and experimental (Rivista)

Insieme di parole chiave di

• Parole chiave di "Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models" (Insieme di parole chiave)